Abstract：
UNASSIGNED: There is a lack of effective treatment for idiopathic unilateral vocal fold paralysis (IUVFP). A better phonation was reported by patients after laryngeal nerve stimulation during our clinical examination.
UNASSIGNED: This study aims to investigate immediate effect of recurrent laryngeal nerve (RLN) stimulation on phonation in patients with IUVFP.
UNASSIGNED: Sixty-two patients with clinically identified IUVFP underwent RLN stimulation with needle electrodes. Laryngoscopy, acoustic analysis, and voice perception assessment were performed for quantitative comparison of vocal function and voice quality before and after the intervention.
UNASSIGNED: Laryngoscopic images showed a larger motion range of the paralyzed vocal fold (p < .01) and better glottal closure (p < .01) after RLN stimulation. Acoustic analysis revealed that the dysphonia severity index increased significantly (p < .01) while the jitter and shimmer decreased after the intervention (p < .05). According to perceptual evaluation, RLN stimulation significantly increased RBH grades in patients with IUVFP (p < .01). Furthermore, the improvement in voice perception had a moderate positive correlation with the decrease in the glottal closure.
UNASSIGNED: This study shows a short-term improvement of phonation in IUVFP patients after RLN stimulation, which provides proof-of-concept for trialing a controlled delivery of RLN stimulation and assessing durability of any observed responses.
UNASSIGNED: This study aims to investigate immediate effect of recurrent laryngeal nerve (RLN) stimulation on phonation in patients with IUVFP.
UNASSIGNED: Sixty-two patients with clinically identified IUVFP underwent RLN stimulation with needle electrodes. Laryngoscopy, acoustic analysis, and voice perception assessment were performed for quantitative comparison of vocal function and voice quality before and after the intervention.
UNASSIGNED: Laryngoscopic images showed a larger motion range of the paralyzed vocal fold (p < .01) and better glottal closure (p < .01) after RLN stimulation. Acoustic analysis revealed that the dysphonia severity index increased significantly (p < .01) while the jitter and shimmer decreased after the intervention (p < .05). According to perceptual evaluation, RLN stimulation significantly increased RBH grades in patients with IUVFP (p < .01). Furthermore, the improvement in voice perception had a moderate positive correlation with the decrease in the glottal closure.
UNASSIGNED: This study shows a short-term improvement of phonation in IUVFP patients after RLN stimulation, which provides proof-of-concept for trialing a controlled delivery of RLN stimulation and assessing durability of any observed responses.
摘要：
■特发性单侧声带麻痹（IUVFP）缺乏有效的治疗方法。在我们的临床检查中，患者在喉神经刺激后报告了更好的发声。
■本研究旨在研究喉返神经（RLN）刺激对IUVFP患者发声的直接影响。
■62例临床确定的IUVFP患者接受了针状电极的RLN刺激。喉镜检查,声学分析,并进行语音感知评估，以定量比较干预前后的声音功能和语音质量。
■喉镜图像显示，在RLN刺激后，瘫痪的声带的运动范围更大（p<.01）和更好的声门闭合（p<.01）。声学分析显示，在干预后，发声障碍严重程度指数显着增加（p<.01），而抖动和闪光减少（p<.05）。根据感性评价，RLN刺激显著增加IUVFP患者的RBH分级(p<0.01)。此外，语音感知的改善与声门闭合的减少呈中度正相关.
■这项研究表明，在RLN刺激后，IUVFP患者的发声有短期改善，它为试验RLN刺激的受控递送和评估任何观察到的反应的耐久性提供了概念验证。
■本研究旨在研究喉返神经（RLN）刺激对IUVFP患者发声的直接影响。
■62例临床确定的IUVFP患者接受了针状电极的RLN刺激。喉镜检查,声学分析,并进行语音感知评估，以定量比较干预前后的声音功能和语音质量。
■喉镜图像显示，在RLN刺激后，瘫痪的声带的运动范围更大（p<.01）和更好的声门闭合（p<.01）。声学分析显示，在干预后，发声障碍严重程度指数显着增加（p<.01），而抖动和闪光减少（p<.05）。根据感性评价，RLN刺激显著增加IUVFP患者的RBH分级(p<0.01)。此外，语音感知的改善与声门闭合的减少呈中度正相关.
■这项研究表明，在RLN刺激后，IUVFP患者的发声有短期改善，它为试验RLN刺激的受控递送和评估任何观察到的反应的耐久性提供了概念验证。
