Abstract：
Four cytotoxic heptacyclic caged-xanthones [gambogefic acids B-E (1-4)], a cytotoxic hexacyclic caged-xanthone [garcilatelic acid (5)], and four biphenyl derivatives [garcilatelibiphenyls A-D (6-9)] were newly isolated in a phytochemical study of a 50% MeOH/CH2Cl2 extract of Garcinia lateriflora (Clusiaceae). The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines including a vincristine-resistant line. The new caged-xanthones displayed potent activity with IC50 values from 0.5 to 6.7 μM against all tested tumor cell lines.
摘要：
四种细胞毒性七环笼中的黄吨酮[γ-酸B-E（1-4）]，细胞毒性的六环笼中的黄吨酮[加纤酸（5）]，在对50％MeOH/CH2Cl2萃取物的植物化学研究中，新分离出了四种联苯衍生物[garcilatelibiliesA-D（6-9）]。评估分离的化合物对包括长春新碱抗性细胞系在内的五种人肿瘤细胞系的抗增殖活性。新的笼状黄吨酮对所有测试的肿瘤细胞系显示出有效的活性，IC50值为0.5至6.7μM。
