{Reference Type}: Journal Article
{Title}: Caged Xanthones and Biphenyls Isolated from the Tropical Plant Garcinia lateriflora.
{Author}: Kobayashi A;Saito Y;Miyake K;Fukuyoshi S;Newman DJ;O'Keefe BR;Lee KH;Nakagawa-Goto K;
{Journal}: J Nat Prod
{Volume}: 87
{Issue}: 2
{Year}: 2024 02 23
{Factor}: 4.803
{DOI}: 10.1021/acs.jnatprod.3c00934
{Abstract}: Four cytotoxic heptacyclic caged-xanthones [gambogefic acids B-E (1-4)], a cytotoxic hexacyclic caged-xanthone [garcilatelic acid (5)], and four biphenyl derivatives [garcilatelibiphenyls A-D (6-9)] were newly isolated in a phytochemical study of a 50% MeOH/CH2Cl2 extract of Garcinia lateriflora (Clusiaceae). The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines including a vincristine-resistant line. The new caged-xanthones displayed potent activity with IC50 values from 0.5 to 6.7 μM against all tested tumor cell lines.