%0 Journal Article
%T Caged Xanthones and Biphenyls Isolated from the Tropical Plant Garcinia lateriflora.
%A Kobayashi A
%A Saito Y
%A Miyake K
%A Fukuyoshi S
%A Newman DJ
%A O'Keefe BR
%A Lee KH
%A Nakagawa-Goto K
%J J Nat Prod
%V 87
%N 2
%D 2024 02 23
%M 38251859
%F 4.803
%R 10.1021/acs.jnatprod.3c00934
%X Four cytotoxic heptacyclic caged-xanthones [gambogefic acids B-E (1-4)], a cytotoxic hexacyclic caged-xanthone [garcilatelic acid (5)], and four biphenyl derivatives [garcilatelibiphenyls A-D (6-9)] were newly isolated in a phytochemical study of a 50% MeOH/CH2Cl2 extract of Garcinia lateriflora (Clusiaceae). The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines including a vincristine-resistant line. The new caged-xanthones displayed potent activity with IC50 values from 0.5 to 6.7 μM against all tested tumor cell lines.