PDF(Pubmed)
Abstract：
UNASSIGNED: The current recommendations for the management of neonatal polycythemia are that partial exchange transfusion (PET) should be performed if the hematocrit is >70% in an asymptomatic neonate, or if the haematocrit is >65% in a symptomatic neonate. The hemodynamic effects of PET for neonatal polycythemia have not been well researched.
UNASSIGNED: To evaluate the hemodynamic effects of PET in neonates with polycythemia.
UNASSIGNED: Prospective observational study conducted in a neonatal intensive care unit of a tertiary care teaching hospital enrolling 21 neonates with polycythemia who underwent PET. Hemodynamic and echocardiographic parameters were obtained prior to PET and 6 h after procedure.
UNASSIGNED: The mean gestational age of neonates with polycythemia was 35.08 ± 2.35 weeks with a mean birth weight of 1,929 ± 819.2 g. There was a significant improvement noted in heart rate and oxygen saturation post PET procedure (p < 0.05). Right ventricular systolic function parameters showed significant improvement (Tricuspid annular plane systolic excursion, fractional area change, right ventricular output) (p < 0.05). Left ventricular function parameters showed significant improvement (Fractional shortening, left ventricular output, E:A ratio) (p < 0.05). Resolution of symptoms was noted after PET procedure with no adverse events associated with PET.
UNASSIGNED: PET maybe effective in improving heart rate and oxygen saturation levels in polycythemic neonates. It has good short-term hemodynamic stability with improvement in right ventricular systolic, as well as left ventricular systolic and diastolic function. It is a safe and effective procedure with minimal adverse effects. Further studies with larger sample size and a control group would be required to corroborate our findings.
UNASSIGNED: To evaluate the hemodynamic effects of PET in neonates with polycythemia.
UNASSIGNED: Prospective observational study conducted in a neonatal intensive care unit of a tertiary care teaching hospital enrolling 21 neonates with polycythemia who underwent PET. Hemodynamic and echocardiographic parameters were obtained prior to PET and 6 h after procedure.
UNASSIGNED: The mean gestational age of neonates with polycythemia was 35.08 ± 2.35 weeks with a mean birth weight of 1,929 ± 819.2 g. There was a significant improvement noted in heart rate and oxygen saturation post PET procedure (p < 0.05). Right ventricular systolic function parameters showed significant improvement (Tricuspid annular plane systolic excursion, fractional area change, right ventricular output) (p < 0.05). Left ventricular function parameters showed significant improvement (Fractional shortening, left ventricular output, E:A ratio) (p < 0.05). Resolution of symptoms was noted after PET procedure with no adverse events associated with PET.
UNASSIGNED: PET maybe effective in improving heart rate and oxygen saturation levels in polycythemic neonates. It has good short-term hemodynamic stability with improvement in right ventricular systolic, as well as left ventricular systolic and diastolic function. It is a safe and effective procedure with minimal adverse effects. Further studies with larger sample size and a control group would be required to corroborate our findings.
摘要：
■目前对新生儿红细胞增多症的治疗建议是，如果无症状新生儿的血细胞比容>70％，则应进行部分交换输血（PET）。或者如果有症状的新生儿的血细胞比容>65%。PET对新生儿红细胞增多症的血流动力学影响尚未得到很好的研究。
■评价PET对新生儿红细胞增多症的血流动力学影响。
■在三级护理教学医院的新生儿重症监护病房进行的前瞻性观察研究，招募了21名接受PET治疗的红细胞增多症新生儿。在PET之前和手术后6小时获得血液动力学和超声心动图参数。
■红细胞增多症新生儿的平均胎龄为35.08±2.35周，平均出生体重为1,929±819.2g。PET手术后心率和氧饱和度显着改善（p<0.05）。右心室收缩功能参数显着改善（三尖瓣环平面收缩偏移，分数面积变化，右心室输出量)(p<0.05)。左心室功能参数显着改善（缩短，左心室输出量,E:A比率)(p<0.05)。在PET手术后注意到症状的消退,没有与PET相关的不良事件。
■PET可能有效改善红细胞增多症新生儿的心率和氧饱和度。具有良好的短期血流动力学稳定性，改善右心室收缩，以及左心室收缩和舒张功能。这是一个安全有效的程序，副作用最小。需要进行更大样本量和对照组的进一步研究来证实我们的发现。
■评价PET对新生儿红细胞增多症的血流动力学影响。
■在三级护理教学医院的新生儿重症监护病房进行的前瞻性观察研究，招募了21名接受PET治疗的红细胞增多症新生儿。在PET之前和手术后6小时获得血液动力学和超声心动图参数。
■红细胞增多症新生儿的平均胎龄为35.08±2.35周，平均出生体重为1,929±819.2g。PET手术后心率和氧饱和度显着改善（p<0.05）。右心室收缩功能参数显着改善（三尖瓣环平面收缩偏移，分数面积变化，右心室输出量)(p<0.05)。左心室功能参数显着改善（缩短，左心室输出量,E:A比率)(p<0.05)。在PET手术后注意到症状的消退,没有与PET相关的不良事件。
■PET可能有效改善红细胞增多症新生儿的心率和氧饱和度。具有良好的短期血流动力学稳定性，改善右心室收缩，以及左心室收缩和舒张功能。这是一个安全有效的程序，副作用最小。需要进行更大样本量和对照组的进一步研究来证实我们的发现。
