{Reference Type}: Journal Article
{Title}: Hemodynamics in neonates with polycythemia before and after partial exchange transfusion: an observational study.
{Author}: Kallimath A;Kolkur K;Malshe N;Klimek J;Suryawanshi P;
{Journal}: Front Pediatr
{Volume}: 11
{Issue}: 0
{Year}: 2023
{Factor}: 3.569
{DOI}: 10.3389/fped.2023.1296184
{Abstract}: <B>UNASSIGNED: </B>The current recommendations for the management of neonatal polycythemia are that partial exchange transfusion (PET) should be performed if the hematocrit is >70% in an asymptomatic neonate, or if the haematocrit is >65% in a symptomatic neonate. The hemodynamic effects of PET for neonatal polycythemia have not been well researched.<BR><B>UNASSIGNED: </B>To evaluate the hemodynamic effects of PET in neonates with polycythemia.<BR><B>UNASSIGNED: </B>Prospective observational study conducted in a neonatal intensive care unit of a tertiary care teaching hospital enrolling 21 neonates with polycythemia who underwent PET. Hemodynamic and echocardiographic parameters were obtained prior to PET and 6 h after procedure.<BR><B>UNASSIGNED: </B>The mean gestational age of neonates with polycythemia was 35.08 ± 2.35 weeks with a mean birth weight of 1,929 ± 819.2 g. There was a significant improvement noted in heart rate and oxygen saturation post PET procedure (p < 0.05). Right ventricular systolic function parameters showed significant improvement (Tricuspid annular plane systolic excursion, fractional area change, right ventricular output) (p < 0.05). Left ventricular function parameters showed significant improvement (Fractional shortening, left ventricular output, E:A ratio) (p < 0.05). Resolution of symptoms was noted after PET procedure with no adverse events associated with PET.<BR><B>UNASSIGNED: </B>PET maybe effective in improving heart rate and oxygen saturation levels in polycythemic neonates. It has good short-term hemodynamic stability with improvement in right ventricular systolic, as well as left ventricular systolic and diastolic function. It is a safe and effective procedure with minimal adverse effects. Further studies with larger sample size and a control group would be required to corroborate our findings.