Abstract：
BACKGROUND: Mucinous ovarian cancer (MOC) represents a rare entity of ovarian malignant neoplasms. The true incidence could be as low as 3% of all ovarian cancers. The aim of this study is to compare and understand the clinicopathological characteristics of patients with mucinous ovarian cancer, report on the survival rates and evaluate the role of gastrointestinal (GI) endoscopy as part of the peri-operative investigations and the impact it has on the survival rates.
METHODS: This is a retrospective data collection on patients with MOC operated in Nottingham gynaecological oncology centre over a 10-year period. Data were analysed using SPSS software.
RESULTS: 43 cases were included in the final analysis. The median maximal tumour diameter was 180 mm. 32 (74.5 %) and 11 (25.5 %) women presented with unilateral and bilateral tumours respectively. 30 patients (69.7 %) presented with stage 1 disease, 1 (2.3 %) presented with stage 2 disease, 7 women (16.4 %) had stage 3 disease and 1 woman (11.6 %) had stage 4 disease. 41 women had staging surgical procedures and 2 women had limited surgery due to poor performance status. After final histology, 5 cases found to have metastatic disease to the ovary rather than primary MOC. 14 women had GI endoscopy as part of their investigation. The total estimated cost of the endoscopies that have been performed is £5635. Primary GI cancer was diagnosed in 1 case during the endoscopy (1 case of gastric cancer). The 5-year overall survival of the women included in this study is 62.8 %. The 5-year overall survival of the women in the endoscopy and non-endoscopy groups was 60 % and 64.3 % respectively (p-value: 0.767).
CONCLUSIONS: The findings of this study show that the survival rates of patients treated for mucinous ovarian cancer in our centre are similar to other published studies. Our findings do not support the routine use of GI endoscopy in the peri-operative investigations of every patient with MOC due to the non-statistically significant difference in the overall survival.
METHODS: This is a retrospective data collection on patients with MOC operated in Nottingham gynaecological oncology centre over a 10-year period. Data were analysed using SPSS software.
RESULTS: 43 cases were included in the final analysis. The median maximal tumour diameter was 180 mm. 32 (74.5 %) and 11 (25.5 %) women presented with unilateral and bilateral tumours respectively. 30 patients (69.7 %) presented with stage 1 disease, 1 (2.3 %) presented with stage 2 disease, 7 women (16.4 %) had stage 3 disease and 1 woman (11.6 %) had stage 4 disease. 41 women had staging surgical procedures and 2 women had limited surgery due to poor performance status. After final histology, 5 cases found to have metastatic disease to the ovary rather than primary MOC. 14 women had GI endoscopy as part of their investigation. The total estimated cost of the endoscopies that have been performed is £5635. Primary GI cancer was diagnosed in 1 case during the endoscopy (1 case of gastric cancer). The 5-year overall survival of the women included in this study is 62.8 %. The 5-year overall survival of the women in the endoscopy and non-endoscopy groups was 60 % and 64.3 % respectively (p-value: 0.767).
CONCLUSIONS: The findings of this study show that the survival rates of patients treated for mucinous ovarian cancer in our centre are similar to other published studies. Our findings do not support the routine use of GI endoscopy in the peri-operative investigations of every patient with MOC due to the non-statistically significant difference in the overall survival.
摘要：
背景：粘液性卵巢癌（MOC）是一种罕见的卵巢恶性肿瘤。真正的发病率可能低至所有卵巢癌的3%。本研究的目的是比较和了解粘液性卵巢癌患者的临床病理特征，报告生存率，并评估胃肠道（GI）内窥镜检查作为围手术期检查的一部分的作用及其对生存率的影响。
方法：这是诺丁汉妇科肿瘤中心MOC患者10年的回顾性数据收集。数据采用SPSS软件进行分析。
结果：43例纳入最终分析。中位最大肿瘤直径为180mm。32例（74.5％）和11例（25.5％）女性分别出现单侧和双侧肿瘤。30例患者（69.7%）出现1期疾病，1例（2.3%）出现2期疾病，7名妇女（16.4%）患有3期疾病，1名妇女（11.6%）患有4期疾病。41名妇女进行了分期手术，2名妇女由于表现不佳而进行了有限的手术。经过最后的组织学检查，5例发现卵巢而非原发性MOC转移性疾病。作为调查的一部分，14名女性接受了胃肠道内窥镜检查。进行内窥镜检查的估计总成本为5635英镑。胃镜检查中1例诊断为原发性胃肠道癌（1例胃癌）。纳入本研究的女性的5年总生存率为62.8%。内镜组和非内镜组女性的5年总生存率分别为60%和64.3%(p值:0.767)。
结论：这项研究的结果表明，在我们中心接受粘液性卵巢癌治疗的患者的生存率与其他已发表的研究相似。我们的发现不支持在每个MOC患者的围手术期检查中常规使用胃肠道内窥镜检查，因为总生存期的差异无统计学意义。
方法：这是诺丁汉妇科肿瘤中心MOC患者10年的回顾性数据收集。数据采用SPSS软件进行分析。
结果：43例纳入最终分析。中位最大肿瘤直径为180mm。32例（74.5％）和11例（25.5％）女性分别出现单侧和双侧肿瘤。30例患者（69.7%）出现1期疾病，1例（2.3%）出现2期疾病，7名妇女（16.4%）患有3期疾病，1名妇女（11.6%）患有4期疾病。41名妇女进行了分期手术，2名妇女由于表现不佳而进行了有限的手术。经过最后的组织学检查，5例发现卵巢而非原发性MOC转移性疾病。作为调查的一部分，14名女性接受了胃肠道内窥镜检查。进行内窥镜检查的估计总成本为5635英镑。胃镜检查中1例诊断为原发性胃肠道癌（1例胃癌）。纳入本研究的女性的5年总生存率为62.8%。内镜组和非内镜组女性的5年总生存率分别为60%和64.3%(p值:0.767)。
结论：这项研究的结果表明，在我们中心接受粘液性卵巢癌治疗的患者的生存率与其他已发表的研究相似。我们的发现不支持在每个MOC患者的围手术期检查中常规使用胃肠道内窥镜检查，因为总生存期的差异无统计学意义。
