Abstract：
The prevalence of gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) in post-irradiated patients with nasopharyngeal carcinoma (NPC) is unknown.
In a cross-sectional study, 31 NPC and 12 control patients completed questionnaires for GERD/LPR before esophageal manometry and 24-h pH monitoring. The DeMeester score and reflux finding score (RFS) were used to define GERD and LPR, respectively. Risk factors were identified.
51.6% of NPC and 8.3% of control patients, and 77.4% of NPC and 33% of control patients, were GERD-positive and LPR-positive, respectively. The GERD/LPR questionnaire failed to identify either condition in patients with NPC. No parameter differences in esophageal manometry or pneumonia incidence were noted between GERD/LPR-positive and GERD/LPR-negative patients. Post radiotherapy duration, high BMI, lack of chemotherapy, and dysphagia were positive risk factors for GERD/LPR.
A high prevalence of GERD/LPR in patients with post-irradiated NPC exists, but reflux symptoms are inadequate for diagnosis.
In a cross-sectional study, 31 NPC and 12 control patients completed questionnaires for GERD/LPR before esophageal manometry and 24-h pH monitoring. The DeMeester score and reflux finding score (RFS) were used to define GERD and LPR, respectively. Risk factors were identified.
51.6% of NPC and 8.3% of control patients, and 77.4% of NPC and 33% of control patients, were GERD-positive and LPR-positive, respectively. The GERD/LPR questionnaire failed to identify either condition in patients with NPC. No parameter differences in esophageal manometry or pneumonia incidence were noted between GERD/LPR-positive and GERD/LPR-negative patients. Post radiotherapy duration, high BMI, lack of chemotherapy, and dysphagia were positive risk factors for GERD/LPR.
A high prevalence of GERD/LPR in patients with post-irradiated NPC exists, but reflux symptoms are inadequate for diagnosis.
摘要：
背景：鼻咽癌（NPC）放疗后患者中胃食管反流病（GERD）和咽喉反流（LPR）的患病率尚不清楚。
方法：在一项横断面研究中，31例NPC和12例对照患者在食管测压和24小时pH监测之前完成了GERD/LPR问卷。DeMeester评分和反流发现评分（RFS）用于定义GERD和LPR，分别。确定了风险因素。
结果：51.6%的NPC和8.3%的对照患者，和77.4%的NPC和33%的对照患者，GERD阳性和LPR阳性，分别。GERD/LPR问卷未能确定NPC患者的两种情况。在GERD/LPR阳性和GERD/LPR阴性患者之间，食管测压或肺炎发生率的参数没有差异。放疗后持续时间，高BMI,缺乏化疗,吞咽困难是GERD/LPR的积极危险因素。
结论：放疗后的NPC患者存在GERD/LPR的高患病率，但反流症状不足以诊断。
方法：在一项横断面研究中，31例NPC和12例对照患者在食管测压和24小时pH监测之前完成了GERD/LPR问卷。DeMeester评分和反流发现评分（RFS）用于定义GERD和LPR，分别。确定了风险因素。
结果：51.6%的NPC和8.3%的对照患者，和77.4%的NPC和33%的对照患者，GERD阳性和LPR阳性，分别。GERD/LPR问卷未能确定NPC患者的两种情况。在GERD/LPR阳性和GERD/LPR阴性患者之间，食管测压或肺炎发生率的参数没有差异。放疗后持续时间，高BMI,缺乏化疗,吞咽困难是GERD/LPR的积极危险因素。
结论：放疗后的NPC患者存在GERD/LPR的高患病率，但反流症状不足以诊断。
