{Reference Type}: Journal Article
{Title}: The prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux in patients with dysphagia after radiotherapy for nasopharyngeal carcinoma.
{Author}: Ku PKM;Vlantis AC;Hui TSC;Yeung ZWC;Cho RHW;Wong MHK;Lee AKF;Yeung DCM;Chan SYP;Chan BYT;Chang WT;Mok F;Wong KH;Wong JKT;Abdullah V;van Hasselt A;Wu JCY;Tong MCF;
{Journal}: Head Neck
{Volume}: 46
{Issue}: 7
{Year}: 2024 07 18
{Factor}: 3.821
{DOI}: 10.1002/hed.27645
{Abstract}: The prevalence of gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) in post-irradiated patients with nasopharyngeal carcinoma (NPC) is unknown.<BR>In a cross-sectional study, 31 NPC and 12 control patients completed questionnaires for GERD/LPR before esophageal manometry and 24-h pH monitoring. The DeMeester score and reflux finding score (RFS) were used to define GERD and LPR, respectively. Risk factors were identified.<BR>51.6% of NPC and 8.3% of control patients, and 77.4% of NPC and 33% of control patients, were GERD-positive and LPR-positive, respectively. The GERD/LPR questionnaire failed to identify either condition in patients with NPC. No parameter differences in esophageal manometry or pneumonia incidence were noted between GERD/LPR-positive and GERD/LPR-negative patients. Post radiotherapy duration, high BMI, lack of chemotherapy, and dysphagia were positive risk factors for GERD/LPR.<BR>A high prevalence of GERD/LPR in patients with post-irradiated NPC exists, but reflux symptoms are inadequate for diagnosis.