%0 Journal Article
%T The prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux in patients with dysphagia after radiotherapy for nasopharyngeal carcinoma.
%A Ku PKM
%A Vlantis AC
%A Hui TSC
%A Yeung ZWC
%A Cho RHW
%A Wong MHK
%A Lee AKF
%A Yeung DCM
%A Chan SYP
%A Chan BYT
%A Chang WT
%A Mok F
%A Wong KH
%A Wong JKT
%A Abdullah V
%A van Hasselt A
%A Wu JCY
%A Tong MCF
%J Head Neck
%V 46
%N 7
%D 2024 07 18
%M 38235957
%F 3.821
%R 10.1002/hed.27645
%X The prevalence of gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) in post-irradiated patients with nasopharyngeal carcinoma (NPC) is unknown.<BR>In a cross-sectional study, 31 NPC and 12 control patients completed questionnaires for GERD/LPR before esophageal manometry and 24-h pH monitoring. The DeMeester score and reflux finding score (RFS) were used to define GERD and LPR, respectively. Risk factors were identified.<BR>51.6% of NPC and 8.3% of control patients, and 77.4% of NPC and 33% of control patients, were GERD-positive and LPR-positive, respectively. The GERD/LPR questionnaire failed to identify either condition in patients with NPC. No parameter differences in esophageal manometry or pneumonia incidence were noted between GERD/LPR-positive and GERD/LPR-negative patients. Post radiotherapy duration, high BMI, lack of chemotherapy, and dysphagia were positive risk factors for GERD/LPR.<BR>A high prevalence of GERD/LPR in patients with post-irradiated NPC exists, but reflux symptoms are inadequate for diagnosis.