PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to explore the relationship between baseline bicarbonate levels and 30-day mortality in individuals with non-traumatic subarachnoid hemorrhage (SAH).
UNASSIGNED: Patients with non-traumatic SAH were chosen from the Medical Information Mart for Intensive Care (MIMIC)-IV database. The relationship between baseline bicarbonate and 30-day mortality was examined using Cox regression models. Restricted cubic splines were used to test the hypothesis that there was an association between bicarbonate and mortality. With the use of Kaplan-Meier survival curve analysis, we looked deeper into the validity of these correlations. To find subgroups with differences, interaction tests were utilized.
UNASSIGNED: This retrospective cohort study consisted of 521 participants in total. Bicarbonate had a negative association with death at 30 days (HR = 0.93, 95%CI: 0.88-0.98, p = 0.004). Next, we divided bicarbonate into quartile groups. In comparison to the reference group Q1 (20 mEq/L), groups Q3 (23-25 mEq/L) and Q4 (26 mEq/L) had adjusted HR values of 0.47 (95%CI: 0.27-0.82, p = 0.007) and 0.56 (95%CI: 0.31-0.99, p = 0.047). No definite conclusions can be derived from this study, since there is no obvious curve link between baseline bicarbonate and 30-day mortality. Patients\' 30-day mortality increased statistically significantly (p < 0.001, K-M analysis) in patients with low bicarbonate levels. The relationship between bicarbonate and 30-day mortality remained consistent in the stratified analysis, with no observed interactions.
UNASSIGNED: Finally, 30-day mortality was negatively associated with baseline bicarbonate levels. Patients with non-traumatic SAH are more at risk of mortality if their bicarbonate levels are low.
UNASSIGNED: Patients with non-traumatic SAH were chosen from the Medical Information Mart for Intensive Care (MIMIC)-IV database. The relationship between baseline bicarbonate and 30-day mortality was examined using Cox regression models. Restricted cubic splines were used to test the hypothesis that there was an association between bicarbonate and mortality. With the use of Kaplan-Meier survival curve analysis, we looked deeper into the validity of these correlations. To find subgroups with differences, interaction tests were utilized.
UNASSIGNED: This retrospective cohort study consisted of 521 participants in total. Bicarbonate had a negative association with death at 30 days (HR = 0.93, 95%CI: 0.88-0.98, p = 0.004). Next, we divided bicarbonate into quartile groups. In comparison to the reference group Q1 (20 mEq/L), groups Q3 (23-25 mEq/L) and Q4 (26 mEq/L) had adjusted HR values of 0.47 (95%CI: 0.27-0.82, p = 0.007) and 0.56 (95%CI: 0.31-0.99, p = 0.047). No definite conclusions can be derived from this study, since there is no obvious curve link between baseline bicarbonate and 30-day mortality. Patients\' 30-day mortality increased statistically significantly (p < 0.001, K-M analysis) in patients with low bicarbonate levels. The relationship between bicarbonate and 30-day mortality remained consistent in the stratified analysis, with no observed interactions.
UNASSIGNED: Finally, 30-day mortality was negatively associated with baseline bicarbonate levels. Patients with non-traumatic SAH are more at risk of mortality if their bicarbonate levels are low.
摘要：
■本研究旨在探讨非创伤性蛛网膜下腔出血（SAH）患者的基线碳酸氢盐水平与30天死亡率之间的关系。
■非创伤性SAH患者选自重症监护医学信息集市(MIMIC)-IV数据库。使用Cox回归模型检查基线碳酸氢盐与30天死亡率之间的关系。使用限制性三次样条来检验碳酸氢盐与死亡率之间存在关联的假设。使用Kaplan-Meier生存曲线分析，我们更深入地研究了这些相关性的有效性。要找到有差异的子群，利用交互测试。
■这项回顾性队列研究共有521名参与者。碳酸氢盐与30天死亡呈负相关(HR=0.93,95CI:0.88-0.98,p=0.004)。接下来,我们把碳酸氢盐分成四分位数组。与参考组Q1(20mEq/L)相比，Q3组(23-25mEq/L)和Q4组(26mEq/L)的校正HR值为0.47(95CI:0.27-0.82,p=0.007)和0.56(95CI:0.31-0.99,p=0.047)。从这项研究中无法得出明确的结论，因为基线碳酸氢盐和30天死亡率之间没有明显的曲线联系。在低碳酸氢盐水平的患者中，患者30天死亡率显著增加（p<0.001，K-M分析）。碳酸氢盐和30天死亡率之间的关系在分层分析中保持一致，没有观察到的相互作用。
■最后，30天死亡率与基线碳酸氢盐水平呈负相关。如果碳酸氢盐水平低，非创伤性SAH患者的死亡风险更高。
■非创伤性SAH患者选自重症监护医学信息集市(MIMIC)-IV数据库。使用Cox回归模型检查基线碳酸氢盐与30天死亡率之间的关系。使用限制性三次样条来检验碳酸氢盐与死亡率之间存在关联的假设。使用Kaplan-Meier生存曲线分析，我们更深入地研究了这些相关性的有效性。要找到有差异的子群，利用交互测试。
■这项回顾性队列研究共有521名参与者。碳酸氢盐与30天死亡呈负相关(HR=0.93,95CI:0.88-0.98,p=0.004)。接下来,我们把碳酸氢盐分成四分位数组。与参考组Q1(20mEq/L)相比，Q3组(23-25mEq/L)和Q4组(26mEq/L)的校正HR值为0.47(95CI:0.27-0.82,p=0.007)和0.56(95CI:0.31-0.99,p=0.047)。从这项研究中无法得出明确的结论，因为基线碳酸氢盐和30天死亡率之间没有明显的曲线联系。在低碳酸氢盐水平的患者中，患者30天死亡率显著增加（p<0.001，K-M分析）。碳酸氢盐和30天死亡率之间的关系在分层分析中保持一致，没有观察到的相互作用。
■最后，30天死亡率与基线碳酸氢盐水平呈负相关。如果碳酸氢盐水平低，非创伤性SAH患者的死亡风险更高。
