PDF(Pubmed)
Abstract：
The emergence of multi drug resistant bacterial infections has caused a critical problem with implication on hospitalization and mortality rates. This systematic review aims to review the combined antimicrobial effect of nanoparticles attached to the traditionally used antibiotics, to overcome the antibiotic resistance crisis. In this systematic search we focused on preclinical studies that have used animal models, to test and evaluate the effect of nanomaterials added to antibiotics against gram negative bacteria with carbapenem resistance. Where, this newly formed structure has led to significant decrease in bacterial load in animal model serum. Furthermore, by evaluating nanomaterial cytotoxicity and inflammatory markers, promising results were established, where low toxicity indices were presented, supporting the ability of this new pathway to be used as an alternative to abused antibiotics. Our research collected the various data and showed encouraging preclinical one for using nanomaterials with antibiotics. This undeniable route should be considered, due to its ability to contribute to the treatment of multi drug resistant bacterial infections. These findings provide base for future studies and reinforce the need for more evaluation and testing on the safety of nanomaterials against bacterial infections.
摘要：
多药耐药细菌感染的出现引起了严重的问题，涉及住院率和死亡率。本系统综述旨在回顾纳米粒子与传统使用的抗生素的联合抗菌作用。克服抗生素耐药性危机。在这个系统的搜索中，我们专注于使用动物模型的临床前研究，试验和评价在抗生素中添加纳米材料对耐碳青霉烯类革兰氏阴性菌的效果。Where,这种新形成的结构导致动物模型血清中细菌负荷的显著降低。此外，通过评估纳米材料的细胞毒性和炎症标志物，建立了有希望的结果，低毒性指数，支持这一新途径作为替代滥用抗生素的能力。我们的研究收集了各种数据，并显示出令人鼓舞的临床前使用纳米材料和抗生素。应该考虑这种不可否认的路线，由于其有助于治疗多药耐药细菌感染的能力。这些发现为未来的研究提供了基础，并加强了对纳米材料对细菌感染的安全性进行更多评估和测试的需求。
