PDF(Pubmed)
Abstract：
BACKGROUND: There are no standards for evaluating skin photoaging. Dermoscopy is a non-invasive detection method that might be useful for evaluating photoaging.
OBJECTIVE: To assess the correlation between the dermoscopic evaluation of photoaging and clinical and pathological evaluations.
METHODS: The age, clinical evaluation (Fitzpatrick classification, Glogau Photoaging Classification, and Chung\'s standardized image ruler), histopathology (Masson staining and MMP-1 immunohistochemistry), and dermoscopy (Hu\'s and Isik\'s) of 40 donor skin samples were analyzed statistically, and Spearman rank correlation analysis was performed.
RESULTS: There was a robust correlation between the total Hu scores and Isik dermoscopy. The correlation of dermoscopy with histopathology was higher than that of clinical evaluation methods. There is a strong correlation between telangiectases and lentigo. Xerosis, superficial wrinkle, diffuse erythema, telangiectases, and reticular pigmentation were significantly correlated with the three clinical evaluation methods. Superficial wrinkles were correlated with Masson, MMP-1, various clinical indicators, and other dermoscopic items.
CONCLUSIONS: There is a good correlation between dermoscopy and clinical and histopathological examination. Dermoscopy might help evaluate skin photoaging.
OBJECTIVE: To assess the correlation between the dermoscopic evaluation of photoaging and clinical and pathological evaluations.
METHODS: The age, clinical evaluation (Fitzpatrick classification, Glogau Photoaging Classification, and Chung\'s standardized image ruler), histopathology (Masson staining and MMP-1 immunohistochemistry), and dermoscopy (Hu\'s and Isik\'s) of 40 donor skin samples were analyzed statistically, and Spearman rank correlation analysis was performed.
RESULTS: There was a robust correlation between the total Hu scores and Isik dermoscopy. The correlation of dermoscopy with histopathology was higher than that of clinical evaluation methods. There is a strong correlation between telangiectases and lentigo. Xerosis, superficial wrinkle, diffuse erythema, telangiectases, and reticular pigmentation were significantly correlated with the three clinical evaluation methods. Superficial wrinkles were correlated with Masson, MMP-1, various clinical indicators, and other dermoscopic items.
CONCLUSIONS: There is a good correlation between dermoscopy and clinical and histopathological examination. Dermoscopy might help evaluate skin photoaging.
摘要：
背景：没有评估皮肤光老化的标准。皮肤镜检查是一种非侵入性检测方法，可用于评估光老化。
目的：评估皮肤光老化评估与临床和病理评估之间的相关性。
方法：年龄，临床评估(Fitzpatrick分类法，Glogau光老化分类，和Chung的标准化图像标尺)，组织病理学（Masson染色和MMP-1免疫组织化学），和皮肤镜检查（Hu's和Isik's）对40个供体皮肤样本进行统计学分析，进行Spearman秩相关分析。
结果：Hu总分与Isik皮肤镜检查之间存在强相关性。皮肤镜检查与组织病理学的相关性高于临床评估方法。毛细血管扩张酶与扁桃体之间有很强的相关性。干燥症,浅层皱纹,弥漫性红斑,毛细血管扩张酶,网状色素沉着与三种临床评价方法显著相关。浅表皱纹与Masson相关，MMP-1，各种临床指标，和其他皮肤镜件。
结论：皮肤镜检查与临床和组织病理学检查有良好的相关性。皮肤镜检查可能有助于评估皮肤光老化。
目的：评估皮肤光老化评估与临床和病理评估之间的相关性。
方法：年龄，临床评估(Fitzpatrick分类法，Glogau光老化分类，和Chung的标准化图像标尺)，组织病理学（Masson染色和MMP-1免疫组织化学），和皮肤镜检查（Hu's和Isik's）对40个供体皮肤样本进行统计学分析，进行Spearman秩相关分析。
结果：Hu总分与Isik皮肤镜检查之间存在强相关性。皮肤镜检查与组织病理学的相关性高于临床评估方法。毛细血管扩张酶与扁桃体之间有很强的相关性。干燥症,浅层皱纹,弥漫性红斑,毛细血管扩张酶,网状色素沉着与三种临床评价方法显著相关。浅表皱纹与Masson相关，MMP-1，各种临床指标，和其他皮肤镜件。
结论：皮肤镜检查与临床和组织病理学检查有良好的相关性。皮肤镜检查可能有助于评估皮肤光老化。
