背景:Q开关(QS)Nd:YAG激光是太阳扁桃体(SLs)的治疗选择之一。然而,炎症后色素沉着(PIH)的发生率是常见的并发症,尤其是深色皮肤。已报道异丁基酰胺基噻唑基间苯二酚(ITR)是紫外线B(UVB)引起的色素沉着过度的预防方式。
目的:本研究旨在评估ITR预防激光诱发的PIH的有效性和安全性。
方法:随机,进行了包括24名SL受试者的评估者盲法研究。每位患者的三个SL被随机分为三组,每天应用两次ITR,每天一次,两周内没有申请。此后,进行532-nmQSNd:YAG激光。激光诱发PIH的发生率,相对黑色素指数(RMI),平均亮度得分(L*),色素沉着过度评分,并记录激光后2个月的不良事件.
结果:与未应用组相比,每天两次的ITR组激光治疗后第4周的PIH发生率显着降低(20.83%vs.50%,p=0.028)。RMI差异无统计学意义,平均L*,和所有就诊之间的色素沉着过度评分。未报告关于ITR应用和激光治疗的严重不良事件。
结论:在QS:NdYAG激光治疗前两周应用ITR可能会降低PIH的发生率。应用时间较长,包括激光手术后,可能更有利于预防激光诱发的PIH。
BACKGROUND: Q-switched (QS) Nd: YAG laser is one of the treatment options for solar lentigines (SLs). However, the incidence of post-inflammatory hyperpigmentation (PIH) is a common complication, especially in dark-complexioned skin. Isobutylamido thiazolyl resorcinol (ITR) has been reported as a preventive modality for ultraviolet B (UVB)-induced hyperpigmentation.
OBJECTIVE: This study aims to evaluate the efficacy and safety of ITR for the prevention of laser-induced PIH.
METHODS: A randomized, evaluator-blinded study including 24 subjects with SLs was conducted. Three SLs of each patient were randomized into three groups, which were to apply ITR twice daily, once daily, and no application for 2 weeks. Thereafter, 532-nm QS Nd: YAG laser was performed. Incidence of laser-induced PIH, relative melanin index (RMI), mean luminance score (L*), hyperpigmentation score, and adverse events were recorded for 2 months post-laser.
RESULTS: The incidence of PIH at the 4th week after laser treatment was significantly lower in the ITR twice-daily group compared to the no-application group (20.83% vs. 50%, p = 0.028). There was no statistically significant difference in RMI, mean L*, and hyperpigmentation score between treatments at all visits. No serious adverse events were reported regarding ITR application and laser treatment.
CONCLUSIONS: Two-week application of ITR prior to QS: Nd YAG laser treatment may potentially reduce the incidence of PIH. A longer duration of application, including after the laser procedure, may be more beneficial for the prevention of laser-induced PIH.