PDF(Pubmed)
Abstract：
Chen et al. recently related the skin autofluorescence (SAF) of Advanced Glycation End-products to subclinical cardiovascular disease in the 3001 participants from the general population (Rotterdam study), with a particularly close relationship for the 413 subjects with diabetes. Because conventional vascular risk factors do not capture the risk in diabetes very well, this relationship may help to select high-risk individuals for the screening of silent myocardial ischemia, which has yet to prove its benefit in randomized controlled trials. Among 477 patients with uncontrolled and/or complicated Type 2 Diabetes, we measured the SAF ten years ago, and we registered new revascularizations during a 54-months follow-up. The patients with SAF > 2.6 Arbitrary units (AUs), the median population value, experienced more revascularizations of the coronary (17/24) and lower-limb arteries (13/17) than patients with a lower SAF, adjusted for age, sex, diabetes duration, vascular complications, and smoking habits: HR 2.17 (95% CI: 1.05-4.48), p = 0.035. The SAF has already been reported to predict cardiovascular events in three cohorts of people with diabetes. We suggest that its measurement may help to improve the performance of the screening before vascular explorations and revascularizations.
摘要：
Chenetal.最近将晚期糖基化终产物的皮肤自发荧光（SAF）与来自普通人群的3001名参与者的亚临床心血管疾病有关（鹿特丹研究），与413名糖尿病患者的关系特别密切。因为传统的血管危险因素不能很好地捕捉糖尿病的风险，这种关系可能有助于选择高风险个体进行无症状心肌缺血的筛查，尚未在随机对照试验中证明其益处。在477例未控制和/或复杂的2型糖尿病患者中，我们十年前测量了苏丹武装部队，在54个月的随访中，我们记录了新的血运重建。SAF>2.6任意单位(AU)的患者，人口中位数值，与SAF较低的患者相比，经历了更多的冠状动脉（17/24）和下肢动脉（13/17）的血运重建，根据年龄调整，性别,糖尿病持续时间，血管并发症,和吸烟习惯：HR2.17（95%CI：1.05-4.48），p=0.035。据报道，SAF可以预测三个糖尿病患者的心血管事件。我们建议其测量可能有助于改善血管探查和血运重建之前的筛查性能。
