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Abstract：
Mycobacterium leprae, the pathogen that causes human leprosy, has a unique affinity for infecting and persisting inside Schwann cells, the principal glia of the peripheral nervous system. Several studies have focused on this intricate host-pathogen interaction as an attempt to advance the current knowledge of the mechanisms governing nerve destruction and disease progression. However, during the chronic course of leprosy neuropathy, Schwann cells can respond to and internalize both live and dead M. leprae and bacilli-derived antigens, and this may result in divergent cellular pathobiological responses. This may also distinctly contribute to tissue degeneration, failure to repair, inflammatory reactions, and nerve fibrosis, hallmarks of the disease. Therefore, the present study systematically searched for published studies on M. leprae-Schwann cell interaction in vitro to summarize the findings and provide a focused discussion of Schwann cell dynamics following challenge with leprosy bacilli.
摘要：
麻风分枝杆菌,导致人类麻风病的病原体，对施万细胞内的感染和持续具有独特的亲和力，周围神经系统的主要神经胶质.一些研究集中在这种复杂的宿主-病原体相互作用上，试图推进目前对神经破坏和疾病进展机制的认识。然而,在麻风病神经病的慢性过程中，雪旺氏细胞可以对活的和死的麻风分枝杆菌和杆菌衍生的抗原作出反应并内化，这可能导致不同的细胞病理生物学反应。这也可能明显导致组织退化，未能修复，炎症反应，和神经纤维化，疾病的标志。因此,本研究系统地搜索了已发表的关于麻风分枝杆菌-雪旺氏细胞体外相互作用的研究，以总结研究结果，并对麻风杆菌攻击后的雪旺氏细胞动力学进行了重点讨论。
