PDF(Pubmed)
Abstract：
ADAR (Adenosine Deaminases Acting on RNA) proteins are a group of enzymes that play a vital role in RNA editing by converting adenosine to inosine in RNAs. This process is a frequent post-transcriptional event observed in metazoan transcripts. Recent studies indicate widespread dysregulation of ADAR-mediated RNA editing across many immune-related diseases, such as human cancer. We comprehensively review ADARs\' function as pattern recognizers and their capability to contribute to mediating immune-related pathways. We also highlight the potential role of site-specific RNA editing in maintaining homeostasis and its relationship to various diseases, such as human cancers. More importantly, we summarize the latest cutting-edge computational approaches and data resources for predicting and analyzing RNA editing sites. Lastly, we cover the recent advancement in site-directed ADAR editing tool development. This review presents an up-to-date overview of ADAR-mediated RNA editing, how site-specific RNA editing could potentially impact disease pathology, and how they could be harnessed for therapeutic applications.
摘要：
ADAR（作用于RNA的腺苷脱氨酶）蛋白是一组酶，通过将腺苷转化为RNA中的肌苷，在RNA编辑中起着至关重要的作用。该过程是在后生动物转录物中观察到的频繁的转录后事件。最近的研究表明，ADAR介导的RNA编辑在许多免疫相关疾病中普遍存在失调。比如人类癌症。我们全面回顾了ADAR作为模式识别者的功能及其介导免疫相关途径的能力。我们还强调了位点特异性RNA编辑在维持稳态及其与各种疾病的关系中的潜在作用。比如人类癌症。更重要的是,我们总结了用于预测和分析RNA编辑位点的最新尖端计算方法和数据资源。最后,我们介绍了网站定向ADAR编辑工具开发的最新进展。这篇综述介绍了ADAR介导的RNA编辑的最新概述，位点特异性RNA编辑如何潜在地影响疾病病理学，以及如何将它们用于治疗应用。
