PDF(Pubmed)
Abstract：
Healthcare-associated infections caused by multi-drug-resistant pathogens are increasing globally, and current antimicrobial options have limited efficacy against these robust species. The WHO details the critically important bacterial and fungal species that are often associated with medical device HAIs. The effective sterilization of medical devices plays a key role in preventing infectious disease morbidity and mortality. A lack of adherence to protocol and limitations associated with each sterilization modality, however, allows for the incidence of disease. Furthermore, issues relating to carcinogenic emissions from ethylene oxide gas (EtO) have motivated the EPA to propose limiting EtO use or seeking alternative sterilization methods for medical devices. The Food and Drug Administration supports the sterilization of healthcare products using low-temperature VH2O2 as an alternative to EtO. With advances in biomaterial and medical devices and the increasing use of combination products, current sterilization modalities are becoming limited. Novel approaches to disinfection and sterilization of medical devices, biomaterials, and therapeutics are warranted to safeguard public health. Bacteriophages, endolysins, and antimicrobial peptides are considered promising options for the prophylactic and meta-phylactic control of infectious diseases. This timely review discusses the application of these biologics as antimicrobial agents against critically important WHO pathogens, including ESKAPE bacterial species.
摘要：
由多重耐药病原体引起的医疗保健相关感染正在全球增加，和目前的抗微生物选择对这些强大的物种的功效有限。WHO详细介绍了通常与医疗器械HAIs相关的至关重要的细菌和真菌物种。医疗器械的有效灭菌在预防传染病发病率和死亡率方面起着关键作用。缺乏对协议的遵守和与每种灭菌方式相关的限制，然而,允许疾病的发生。此外，与环氧乙烷气体（EtO）的致癌排放有关的问题促使EPA提议限制EtO的使用或寻求医疗设备的替代灭菌方法。美国食品和药物管理局支持使用低温VH2O2作为EtO的替代品对医疗保健产品进行灭菌。随着生物材料和医疗设备的进步以及组合产品的使用越来越多，目前的灭菌方式变得有限。医疗设备消毒和灭菌的新方法，生物材料,和治疗有必要保障公众健康。噬菌体,内溶素,和抗菌肽被认为是预防和预防传染病的有希望的选择。这一及时的审查讨论了这些生物制剂作为抗微生物剂的应用，以对抗至关重要的世卫组织病原体，包括ESKAPE细菌物种。
