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Abstract：
Progressive cerebral infarction (PCI) is a common complication in patients with ischemic stroke that leads to poor prognosis. Blood pressure (BP) can indicate post-stroke hemodynamic changes which play a key role in the development of PCI. The authors aim to investigate the association between BP-derived hemodynamic parameters and PCI. Clinical data and BP recordings were collected from 80 patients with cerebral infarction, including 40 patients with PCI and 40 patients with non-progressive cerebral infarction (NPCI). Hemodynamic parameters were calculated from the BP recordings of the first 7 days after admission, including systolic and diastolic BP, mean arterial pressure, and pulse pressure (PP), with the mean values of each group calculated and compared between daytime and nighttime, and between different days. Hemodynamic parameters and circadian BP rhythm patterns were compared between PCI and NPCI groups using t-test or non-parametric equivalent for continuous variables, Chi-squared test or Fisher\'s exact test for categorical variables, Cox proportional hazards regression analysis and binary logistic regression analysis for potential risk factors. In PCI and NPCI groups, significant decrease of daytime systolic BP appeared on the second and sixth days, respectively. Systolic BP and fibrinogen at admission, daytime systolic BP of the first day, nighttime systolic BP of the third day, PP, and the ratio of abnormal BP circadian rhythms were all higher in the PCI group. PCI and NPCI groups were significantly different in BP circadian rhythm pattern. PCI is associated with higher systolic BP, PP and more abnormal circadian rhythms of BP.
摘要：
进展性脑梗死（PCI）是缺血性卒中患者常见的并发症，导致预后不良。血压（BP）可以指示卒中后的血流动力学变化，这在PCI的发展中起关键作用。作者旨在研究BP衍生的血流动力学参数与PCI之间的关联。收集80例脑梗死患者的临床资料和血压记录，包括40例PCI患者和40例非进展性脑梗死（NPCI）患者。根据入院后最初7天的血压记录计算血流动力学参数，包括收缩压和舒张压,平均动脉压,和脉压（PP），计算每组的平均值，并在白天和晚上进行比较，在不同的日子之间。采用t检验或连续变量的非参数等值法比较PCI组和NPCI组的血流动力学参数和昼夜节律,分类变量的卡方检验或Fisher精确检验，潜在危险因素的Cox比例风险回归分析和二元logistic回归分析。在PCI和NPCI组中，第2天和第6天出现日间收缩压显著下降，分别。入院时收缩压和纤维蛋白原，第一天的白天收缩压，第三天的夜间收缩压,PP,PCI组血压昼夜节律异常的比率均较高。PCI组和NPCI组的血压昼夜节律有显著差异。PCI与较高的收缩压相关，PP和BP的昼夜节律异常较多。
