PDF(Pubmed)
Abstract：
BACKGROUND: Sensitive skin is a common condition affecting a significant proportion of the population, and there is a growing demand for effective and safe management.
OBJECTIVE: To evaluate the efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate as an optimal care for facial sensitive skin.
METHODS: A total of 110 participants (64 in group A and 46 in group B) with facial sensitive skin applied the cream twice daily for 28 days. Group A evaluated their sensitive skin, product efficacy, and product use experience at D0 (15 min), D1, D14, and D28. In group B, skin barrier function-related indicators were measured at baseline and on D1, D7, D14, and D28. Dermatologists evaluated tolerance for all participants.
RESULTS: After 28 days of use, in group A, 100% of participants reported mildness and comfort with product use. Participants demonstrated significant improvements in skin barrier function-related indicators, including increased stratum corneum moisture content, reduced erythema index, elevated sebum content, decreased trans-epidermal water loss, and diminished skin redness parameter a* value (all p < 0.05). Dermatologist evaluations revealed excellent tolerance among all participants.
CONCLUSIONS: The panthenol-enriched cream with prebiotics and probiotic lysate exhibited substantial clinical efficacy in ameliorating facial sensitive skin conditions, coupled with a high safety profile.
OBJECTIVE: To evaluate the efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate as an optimal care for facial sensitive skin.
METHODS: A total of 110 participants (64 in group A and 46 in group B) with facial sensitive skin applied the cream twice daily for 28 days. Group A evaluated their sensitive skin, product efficacy, and product use experience at D0 (15 min), D1, D14, and D28. In group B, skin barrier function-related indicators were measured at baseline and on D1, D7, D14, and D28. Dermatologists evaluated tolerance for all participants.
RESULTS: After 28 days of use, in group A, 100% of participants reported mildness and comfort with product use. Participants demonstrated significant improvements in skin barrier function-related indicators, including increased stratum corneum moisture content, reduced erythema index, elevated sebum content, decreased trans-epidermal water loss, and diminished skin redness parameter a* value (all p < 0.05). Dermatologist evaluations revealed excellent tolerance among all participants.
CONCLUSIONS: The panthenol-enriched cream with prebiotics and probiotic lysate exhibited substantial clinical efficacy in ameliorating facial sensitive skin conditions, coupled with a high safety profile.
摘要：
背景：敏感性皮肤是影响相当一部分人口的常见疾病，对有效和安全管理的需求日益增长。
目的：为了评价含有泛醇的乳膏的疗效和安全性，益生元,和益生菌裂解物作为面部敏感皮肤的最佳护理。
方法：共有110名面部敏感皮肤的参与者（A组64名，B组46名）每天两次涂抹乳膏，持续28天。A组评估了他们敏感的皮肤，产品功效,和D0时的产品使用经验（15分钟），D1、D14和D28。B组,在基线和D1,D7,D14和D28测量皮肤屏障功能相关指标.皮肤科医生评估了所有参与者的耐受性。
结果：使用28天后，A组,100％的参与者报告了产品使用的温和和舒适。参与者表现出皮肤屏障功能相关指标的显着改善，包括角质层水分含量增加，红斑指数降低，皮脂含量升高,减少经表皮水分流失，和减少的皮肤发红参数a*值(所有p<0.05)。皮肤科医生的评估显示，所有参与者的耐受性都很好。
结论：含有益生元和益生菌裂解物的富含泛醇的乳膏在改善面部敏感性皮肤状况方面表现出显著的临床疗效，加上高度的安全形象。
目的：为了评价含有泛醇的乳膏的疗效和安全性，益生元,和益生菌裂解物作为面部敏感皮肤的最佳护理。
方法：共有110名面部敏感皮肤的参与者（A组64名，B组46名）每天两次涂抹乳膏，持续28天。A组评估了他们敏感的皮肤，产品功效,和D0时的产品使用经验（15分钟），D1、D14和D28。B组,在基线和D1,D7,D14和D28测量皮肤屏障功能相关指标.皮肤科医生评估了所有参与者的耐受性。
结果：使用28天后，A组,100％的参与者报告了产品使用的温和和舒适。参与者表现出皮肤屏障功能相关指标的显着改善，包括角质层水分含量增加，红斑指数降低，皮脂含量升高,减少经表皮水分流失，和减少的皮肤发红参数a*值(所有p<0.05)。皮肤科医生的评估显示，所有参与者的耐受性都很好。
结论：含有益生元和益生菌裂解物的富含泛醇的乳膏在改善面部敏感性皮肤状况方面表现出显著的临床疗效，加上高度的安全形象。
