METHODS: BC cases and controls were enrolled in three sub-Saharan African countries, Nigeria, Cameroon, and Uganda, between 1998 and 2018. Multivariable logistic regression was used to test the association between BBD and BC. Risk factors dually associated with BBD and BC were selected. Using a parametric mediation analysis model, we assessed if selected BC risk factors were mediated by BBD.
RESULTS: Of 6,274 participants, 55.6% (3,478) were breast cancer cases. 360 (5.7%) self-reported BBD. Fibroadenoma (46.8%) was the most commonly reported BBD. Women with a self-reported history of BBD had greater odds of developing BC than those without (adjusted odds ratio [aOR] 1.47, 95% CI 1.13-1.91). Biopsy-confirmed BBD was associated with BC (aOR 2.25, 95% CI 1.26-4.02). BBD did not significantly mediate the effects of any of the selected BC risk factors.
CONCLUSIONS: In this study, BBD was associated with BC and did not significantly mediate the effects of selected BC risk factors.
方法:在三个撒哈拉以南非洲国家登记了BC病例和对照,尼日利亚,喀麦隆,乌干达,1998年至2018年。采用多变量logistic回归分析BBD与BC的相关性。选择与BBD和BC双重相关的危险因素。使用参数中介分析模型,我们评估了选定的BC危险因素是否由BBD介导。
结果:在6,274名参与者中,55.6%(3,478例)为乳腺癌。360(5.7%)自我报告BBD。纤维腺瘤(46.8%)是最常见的BBD。自我报告有BBD病史的女性比没有BBD病史的女性发生BC的几率更大(调整后的比值比[aOR]1.47,95%CI1.13-1.91)。活检证实的BBD与BC相关(aOR2.25,95%CI1.26-4.02)。BBD没有显著介导任何选定的BC危险因素的作用。
结论:在这项研究中,BBD与BC相关,并不显著介导选定BC危险因素的影响。