Abstract：
Silk fibroin (SF) from the silkworm Bombyx mori is a fibrous protein identified as a widely suitable biomaterial due to its biocompatibility, tunable degradation, and mechanical strength. Various modifications of SF protein can give SF fibers new properties and functions, broadening their applications in textile and biomedical industries. A diverse array of functional modifications on various forms of SF has been reported. In order to provide researchers with a more systematic understanding of the types of functional modifications of SF protein, as well as the corresponding applications, we comprehensively review the different types of functional modifications, including transgenic modification, modifications with chemical groups or biologically active substance, cross-linking and copolymerization without chemical reactions, their specific modification methods and applications. Furthermore, recent applications of SF in various medical biomaterials are briefly discussed.
摘要：
来自家蚕的丝素蛋白（SF）是一种纤维状蛋白，由于其生物相容性而被确定为广泛适用的生物材料，可调降解，和机械强度。SF蛋白的各种修饰可以赋予SF纤维新的性质和功能,扩大其在纺织和生物医学行业的应用。已经报道了对各种形式的SF的各种功能修饰。为了给研究者更系统的了解SF蛋白的功能修饰类型,以及相应的应用程序，我们全面回顾了不同类型的功能修改，包括转基因修饰，用化学基团或生物活性物质修饰，没有化学反应的交联和共聚，其具体的修改方法和应用。此外，简要讨论了SF在各种医用生物材料中的最新应用。
