PDF(Pubmed)
Abstract：
Ketamine is a novel and exciting putative antidepressant medication for patients with treatment-resistant depression. A complication commonly seen in frequent and heavy recreational use of ketamine is ulcerative cystitis, which presents with lower urinary tract symptoms (LUTS) and upper renal tract damage and can be seen in over 25% of regular users. Although Ketamine-induced cystitis (KIC) is a recognised complication in recreational use of ketamine, its occurrence in therapeutic use of ketamine in depression has so far not been reported. The exact pathogenesis of KIC is currently unknown, making treatment and prevention advice much more difficult. Early diagnosis of KIC and immediate cessation of ketamine has been shown to improve adverse urinary tract symptoms and prevent further damage.
We present a case of a 28-year-old female who was started on ketamine treatment for depression, and who then developed symptoms of KIC, which was confirmed by urine microscopy, culture and analysis.
To our knowledge, this is the first reported case of KIC in a patient receiving treatment-dose ketamine as part of their antidepressant therapy.
We present a case of a 28-year-old female who was started on ketamine treatment for depression, and who then developed symptoms of KIC, which was confirmed by urine microscopy, culture and analysis.
To our knowledge, this is the first reported case of KIC in a patient receiving treatment-dose ketamine as part of their antidepressant therapy.
摘要：
背景：氯胺酮是一种新的、令人兴奋的抗抑郁剂药物，用于治疗难治性抑郁症患者。经常和大量娱乐使用氯胺酮的常见并发症是溃疡性膀胱炎，表现为下尿路症状（LUTS）和上肾道损害，并且可以在超过25％的常规使用者中看到。尽管氯胺酮诱发的膀胱炎（KIC）是娱乐性使用氯胺酮的公认并发症，迄今为止，尚未报道氯胺酮在抑郁症治疗中的发生。KIC的确切发病机制目前尚不清楚,使治疗和预防建议变得更加困难。KIC的早期诊断和氯胺酮的立即停止已被证明可以改善不良泌尿道症状并防止进一步的损害。
方法：我们介绍一例28岁的女性，她开始服用氯胺酮治疗抑郁症，然后出现了KIC的症状，尿液显微镜证实了这一点，文化与分析。
结论：据我们所知，这是首例接受治疗剂量氯胺酮作为抗抑郁治疗的患者出现KIC的病例.
方法：我们介绍一例28岁的女性，她开始服用氯胺酮治疗抑郁症，然后出现了KIC的症状，尿液显微镜证实了这一点，文化与分析。
结论：据我们所知，这是首例接受治疗剂量氯胺酮作为抗抑郁治疗的患者出现KIC的病例.
