PDF(Pubmed)
Abstract：
UNASSIGNED: Vaccination schedules, as well as their effectiveness and contraindications, need to be evaluated regularly, especially in specific situations. Congenital Zika Syndrome (CZS) is a severe condition that results in extensive functional and neurological impairment of fetuses and newborns due to Zika virus tropism for fetal neural progenitor cells. Down Syndrome (DS) is the leading genetic cause of intellectual disability. The immune impairment in DS has already been described, but little is known about the immune response of CZS children. Thus, CZS and DS are specific conditions that can be considered for a reassessment of the available immunizations. Here, we carried out serological analyses of attenuated vaccines-induced antibodies for measles, rubella, and yellow fever viruses in children aged 2-7, grouped into asymptomatic controls, DS children, and CZS children.
UNASSIGNED: Plasma samples were taken, and vaccination records were compiled during clinical follow-up. Enzymatic immunoassays for quantifying anti-measles and anti-rubella IgG were performed to assess the response to the Measles, Mumps, and Rubella (MMR) vaccine. Plaque Reduction Neutralization Test (PRNT) was performed to investigate neutralizing antibodies in response to the Brazilian vaccine strain of yellow fever (YF-17DD).
UNASSIGNED: We highlight similar levels of anti-measles IgG and neutralizing antibodies for YF-17DD among CZS, DS, and asymptomatic children, although low positivity of measles data was seen in the three groups. In DS children, the 2-4-year-old group had an increased level of anti-measles IgG compared to the older group of children aged five to seven years. Lower anti-rubella IgG levels were observed in CZS and DS children compared to asymptomatic children. For anti-rubella IgG, the good performance of vaccination in asymptomatic children is due to younger ones rather than older ones.
UNASSIGNED: There were no reports of adverse events after the use of the MMR and YF-17DD indicating that CZS and DS could continue to receive these vaccines, but our data draws attention to the necessity of monitoring the vaccination response in CZS and DS children over time and the possible need to adhere to national measles vaccination campaigns. Scientific research needs to continue to help develop appropriate CZS and DS health guidelines.
UNASSIGNED: Plasma samples were taken, and vaccination records were compiled during clinical follow-up. Enzymatic immunoassays for quantifying anti-measles and anti-rubella IgG were performed to assess the response to the Measles, Mumps, and Rubella (MMR) vaccine. Plaque Reduction Neutralization Test (PRNT) was performed to investigate neutralizing antibodies in response to the Brazilian vaccine strain of yellow fever (YF-17DD).
UNASSIGNED: We highlight similar levels of anti-measles IgG and neutralizing antibodies for YF-17DD among CZS, DS, and asymptomatic children, although low positivity of measles data was seen in the three groups. In DS children, the 2-4-year-old group had an increased level of anti-measles IgG compared to the older group of children aged five to seven years. Lower anti-rubella IgG levels were observed in CZS and DS children compared to asymptomatic children. For anti-rubella IgG, the good performance of vaccination in asymptomatic children is due to younger ones rather than older ones.
UNASSIGNED: There were no reports of adverse events after the use of the MMR and YF-17DD indicating that CZS and DS could continue to receive these vaccines, but our data draws attention to the necessity of monitoring the vaccination response in CZS and DS children over time and the possible need to adhere to national measles vaccination campaigns. Scientific research needs to continue to help develop appropriate CZS and DS health guidelines.
摘要：
■疫苗接种时间表，以及它们的有效性和禁忌症，需要定期评估，特别是在特定情况下。先天性寨卡综合症（CZS）是一种严重的疾病，由于寨卡病毒对胎儿神经祖细胞的嗜性，导致胎儿和新生儿广泛的功能和神经系统损害。唐氏综合症（DS）是智力障碍的主要遗传原因。DS的免疫损伤已经被描述，但对CZS儿童的免疫反应知之甚少。因此，CZS和DS是可以考虑用于重新评估可用免疫接种的特定条件。这里,我们对减毒疫苗诱导的麻疹抗体进行了血清学分析，风疹,2-7岁儿童的黄热病病毒，分为无症状对照，DS儿童，和CZS儿童。
■采集血浆样本，并在临床随访期间编制疫苗接种记录.进行定量抗麻疹和抗风疹IgG的酶免疫测定以评估对麻疹的反应，腮腺炎,风疹（MMR）疫苗。进行斑块减少中和试验(PRNT)以研究响应于黄热病的巴西疫苗株(YF-17DD)的中和抗体。
■我们强调CZS中YF-17DD的抗麻疹IgG和中和抗体水平相似，DS,和无症状的儿童，尽管在三组中麻疹数据阳性较低.在DS儿童中，与年龄较大的5~7岁儿童组相比,2~4岁组的抗麻疹IgG水平升高.与无症状儿童相比，CZS和DS儿童的抗风疹IgG水平较低。对于抗风疹IgG，无症状儿童接种疫苗的良好表现是由于年龄较小的儿童而不是年龄较大的儿童。
■使用MMR和YF-17DD后没有不良事件的报告，表明CZS和DS可以继续接受这些疫苗，但我们的数据提请注意,随着时间的推移,监测CZS和DS儿童的疫苗接种反应的必要性,以及可能需要坚持开展全国麻疹疫苗接种运动.科学研究需要继续帮助制定适当的CZS和DS健康指南。
■采集血浆样本，并在临床随访期间编制疫苗接种记录.进行定量抗麻疹和抗风疹IgG的酶免疫测定以评估对麻疹的反应，腮腺炎,风疹（MMR）疫苗。进行斑块减少中和试验(PRNT)以研究响应于黄热病的巴西疫苗株(YF-17DD)的中和抗体。
■我们强调CZS中YF-17DD的抗麻疹IgG和中和抗体水平相似，DS,和无症状的儿童，尽管在三组中麻疹数据阳性较低.在DS儿童中，与年龄较大的5~7岁儿童组相比,2~4岁组的抗麻疹IgG水平升高.与无症状儿童相比，CZS和DS儿童的抗风疹IgG水平较低。对于抗风疹IgG，无症状儿童接种疫苗的良好表现是由于年龄较小的儿童而不是年龄较大的儿童。
■使用MMR和YF-17DD后没有不良事件的报告，表明CZS和DS可以继续接受这些疫苗，但我们的数据提请注意,随着时间的推移,监测CZS和DS儿童的疫苗接种反应的必要性,以及可能需要坚持开展全国麻疹疫苗接种运动.科学研究需要继续帮助制定适当的CZS和DS健康指南。
