■尽管有关寨卡病毒(ZIKV)感染的科学知识不断增加,关于妊娠ZIKV感染和先天性ZIKV综合征(CZS)的问题仍然存在。
ZIKAction儿科登记处是一项国际登记处,登记有记录的子宫内ZIKV暴露和/或确认或疑似CZS的儿童。它的目的是表征这些孩子(即,临床,放射学,神经发育特征)和描述结果,通过回顾性病例记录审查,长期后遗症和管理。这项分析描述了登记处巴伊亚臂中儿童的孕产妇和围产期特征,评估了他们的神经影像学,眼科,听力和脑电图异常通过小头畸形分类和住院报告。包括在2015-2018年出生并在2020-2021年在萨尔瓦多的三个公共卫生设施中注册的儿童。
■在129名(57%为女性)儿童中,15例(11·6%)有实验室确诊的先天性ZIKV感染,114例(88·4%)疑似CZS。交货时,15例(11·6%)为正常头颅,30(23·3%)中度小脑,和84(65·1%)严重的小脑。中位出生头围z评分为-3·51[IQR,-4·69,-2·73]。随访期间,所有的孩子都有异常的神经影像学检查,80·3%(94/117)异常脑电图,62·2%(77/120)眼科异常,27·4%(34/124)听力障碍。小头畸形分类与胎龄显著相关,眼科和脑电图异常。在125名住院儿童中,52人(41·6%)在最近的随访中住院,中位年龄为15·8[4·0,34·4]个月;感染是主要原因。
■先天性ZIKV感染是一种新出现的疾病,具有多种且未完全理解的频谱。持续的长期随访对于了解长期预后并告知未来的健康和教育需求至关重要。
UNASSIGNED: Despite growing scientific knowledge of Zika virus (ZIKV) infection, questions remain regarding ZIKV infection in pregnancy and congenital ZIKV syndrome (CZS).
UNASSIGNED: The ZIKAction Paediatric Registry is an international registry of children with documented ZIKV exposure in utero and/or with confirmed or suspected CZS. Its aim is to characterize these children (i.e., clinical, radiological, neurodevelopmental features) and describe outcomes, longer-term sequelae and management through retrospective case note review. This analysis described the maternal and perinatal characteristics of children in the Registry\'s Bahia arm, assessed their neuroimaging, ophthalmic, hearing and electroencephalography abnormalities by microcephaly classification and reported on hospitalisations. Children born in 2015-2018 and enrolled 2020-2021 in three public health facilities in Salvador were included.
UNASSIGNED: Of 129 (57% female) children, 15 (11·6%) had laboratory-confirmed congenital ZIKV infection and 114 (88·4%) suspected CZS. At delivery, 15 (11·6%) were normocephalic, 30 (23·3%) moderately microcephalic, and 84 (65·1%) severely microcephalic. Median birth head circumference z-score was -3·51 [IQR, -4·69,-2·73]. During follow-up, all children had abnormal neuroimaging, 80·3% (94/117) abnormal electroencephalogram, 62·2% (77/120) ophthalmic abnormalities, and 27·4% (34/124) hearing impairment. Microcephaly classification was significantly associated with gestational age, and ophthalmological and electroencephalography abnormalities. Of 125 children with hospitalisation data, 52 (41·6%) had been hospitalised by most recent follow-up, at median age of 15·8 [4·0, 34·4] months; infections were the leading cause.
UNASSIGNED: Congenital ZIKV infection is an emerging disease with a varied and incompletely understood spectrum. Continued long-term follow-up is essential to understand longer-term prognosis and to inform future health and educational needs.