PDF(Pubmed)
Abstract：
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a drug reaction commonly related to eosinophilia, from uncertain epidemiology, and without consensus for diagnosis and treatment globally. It presents a great challenge in its management and is characterized by fever, lymphadenopathy, skin rash, and multisystemic involvement. An aggressive and difficult-to-manage clinical case is presented in a 50-year-old man with chronic kidney disease due to diabetes mellitus type 2 and systemic arterial hypertension, who developed an unusual variant similar to DRESS and Stevens-Johnson syndrome (SJS) overlap secondary to allopurinol, with skin manifestations without eosinophilia, but fulfilling clinical and laboratory criteria for DRESS and SJS syndrome.
摘要：
伴嗜酸性粒细胞增多和全身症状的药物反应（DRESS）综合征是一种通常与嗜酸性粒细胞增多有关的药物反应，来自不确定的流行病学，并且在全球范围内没有诊断和治疗的共识。它在管理上提出了巨大的挑战，其特点是发烧，淋巴结病，皮疹,和多系统参与。一名50岁的男性因2型糖尿病和全身性动脉高血压而患有慢性肾脏疾病，这是一例侵袭性且难以管理的临床病例。他开发了一种与DRESS和Stevens-Johnson综合征（SJS）相似的异常变异，皮肤表现无嗜酸性粒细胞增多,但符合DRESS和SJS综合征的临床和实验室标准。
