{Reference Type}: Case Reports
{Title}: DRESS and Stevens-Johnson Syndrome Overlap Secondary to Allopurinol in a 50-Year-Old Man-A Diagnostic and Treatment Challenge: Case Report.
{Author}: Martínez JD;Franco R;Sáenz LM;Alvarado AG;García JA;Delgado SM;Ionescu MA;Busilă C;Tatu AL;
{Journal}: Life (Basel)
{Volume}: 13
{Issue}: 12
{Year}: 2023 Nov 24
{Factor}: 3.251
{DOI}: 10.3390/life13122251
{Abstract}: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a drug reaction commonly related to eosinophilia, from uncertain epidemiology, and without consensus for diagnosis and treatment globally. It presents a great challenge in its management and is characterized by fever, lymphadenopathy, skin rash, and multisystemic involvement. An aggressive and difficult-to-manage clinical case is presented in a 50-year-old man with chronic kidney disease due to diabetes mellitus type 2 and systemic arterial hypertension, who developed an unusual variant similar to DRESS and Stevens-Johnson syndrome (SJS) overlap secondary to allopurinol, with skin manifestations without eosinophilia, but fulfilling clinical and laboratory criteria for DRESS and SJS syndrome.