PDF(Pubmed)
Abstract：
This study aimed to summarize the screened articles on antibiotic shortages, compare them with the Hungarian Health Authority database, and identify the overlapping substances in shortages and handling practices. A systematic analysis was conducted using the provided keywords to filter out appropriate studies and incorporate them into this review. The studies were searched in the following databases: Reaxys, PubMed, Ovid, ScienceDirect, and Embase. The search time interval was 2000-2023, with the following keywords used: \"antibiotic\", \"shortage\", and \"in clinic\". The shortage data for Hungary were collected and integrated within the specified timeframe. This was achieved through a comprehensive screening method to ensure comparability between the data from the literature review and the database. Based on the comparison, we have identified two groups of ingredients, the overlapping and not-overlapping ingredients. The mitigation practices were also categorized and evaluated to recommend good shortage management practices for Hungarian decision-makers and healthcare professionals. Our key conclusion was to enhance a shortage risk-based approach, including the legislative, health authority, and healthcare professionals responsible for therapeutic protocol and procuring or producing the necessary product. A widely approved shortage risk-based framework should be created to mitigate the impacts, including communication protocols, individual therapy planning, compounding of magistral products, and antimicrobial stewardship programs. The most common mitigation strategy is the substitution with available alternatives, but besides, a good understanding and implementation of antimicrobial stewardship programs is also crucial.
摘要：
本研究旨在总结筛选的关于抗生素短缺的文章，将它们与匈牙利卫生局的数据库进行比较，并确定短缺和处理实践中的重叠物质。使用提供的关键词进行了系统分析，以筛选出适当的研究并将其纳入本综述。这些研究在以下数据库中进行了搜索：Reaxys，PubMed,奥维德,ScienceDirect,和Embase。搜索时间间隔为2000-2023年，使用以下关键字：\“抗生素\”，\"短缺\",和“在诊所”。匈牙利的短缺数据是在规定的时间范围内收集和整合的。这是通过全面的筛选方法来实现的，以确保文献综述和数据库中的数据之间的可比性。根据比较,我们已经确定了两组成分，重叠和不重叠的成分。还对缓解措施进行了分类和评估，以为匈牙利决策者和医疗保健专业人员推荐良好的短缺管理措施。我们的主要结论是加强基于短缺风险的方法，包括立法，卫生当局,和医疗保健专业人员负责治疗方案和采购或生产必要的产品。应建立广泛认可的基于短缺风险的框架，以减轻影响，包括通信协议，个人治疗计划，裁判官产品的复合，和抗菌药物管理计划。最常见的缓解策略是用可用的替代品进行替代，但除此之外,对抗菌药物管理计划的良好理解和实施也至关重要。
