PDF(Pubmed)
Abstract：
In recent years, antibacterial coatings have become an important approach in the global fight against bacterial pathogens. Developments in materials science, chemistry, and biochemistry have led to a plethora of materials and chemical compounds that have the potential to create antibacterial coatings. However, insufficient attention has been paid to the analysis of the techniques and technologies used to apply these coatings. Among the various inorganic coating techniques, atomic layer deposition (ALD) is worthy of note. It enables the successful synthesis of high-purity inorganic nanocoatings on surfaces of complex shape and topography, while also providing precise control over their thickness and composition. ALD has various industrial applications, but its practical application in medicine is still limited. In recent years, a considerable number of papers have been published on the proposed use of thin films and coatings produced via ALD in medicine, notably those with antibacterial properties. The aim of this paper is to carefully evaluate and analyze the relevant literature on this topic. Simple oxide coatings, including TiO2, ZnO, Fe2O3, MgO, and ZrO2, were examined, as well as coatings containing metal nanoparticles such as Ag, Cu, Pt, and Au, and mixed systems such as TiO2-ZnO, TiO2-ZrO2, ZnO-Al2O3, TiO2-Ag, and ZnO-Ag. Through comparative analysis, we have been able to draw conclusions on the effectiveness of various antibacterial coatings of different compositions, including key characteristics such as thickness, morphology, and crystal structure. The use of ALD in the development of antibacterial coatings for various applications was analyzed. Furthermore, assumptions were made about the most promising areas of development. The final section provides a comparison of different coatings, as well as the advantages, disadvantages, and prospects of using ALD for the industrial production of antibacterial coatings.
摘要：
近年来,抗菌涂料已成为全球对抗细菌病原体的重要途径。材料科学的发展，化学,和生物化学导致了大量的材料和化合物，这些材料和化合物有可能产生抗菌涂层。然而,对应用这些涂料的技术和工艺的分析不够重视。在各种无机涂层技术中，原子层沉积(ALD)是值得注意的。它能够在复杂形状和形貌的表面上成功合成高纯度无机纳米涂层，同时还提供对其厚度和成分的精确控制。ALD有各种工业应用，但其在医学上的实际应用仍然有限。近年来,已经发表了大量关于通过ALD在医学中生产的薄膜和涂层的建议使用的论文，尤其是那些具有抗菌性能的。本文旨在仔细评估和分析有关该主题的相关文献。简单的氧化物涂层，包括TiO2，ZnO，Fe2O3,MgO,和ZrO2进行了检查，以及含有金属纳米颗粒如Ag的涂层，Cu,Pt,Au,和TiO2-ZnO等混合体系，TiO2-ZrO2,ZnO-Al2O3,TiO2-Ag,和ZnO-Ag.通过比较分析,我们已经能够得出不同成分的各种抗菌涂料的有效性的结论，包括厚度等关键特征，形态学,和晶体结构。分析了ALD在开发各种应用的抗菌涂料中的应用。此外，对最有希望的发展领域进行了假设。最后一部分提供了不同涂层的比较，以及优势，缺点,以及使用ALD工业生产抗菌涂料的前景。
