Abstract：
OBJECTIVE: To compare superficial and deep vascular characteristics of the optic disc in retrobulbar optic neuritis using optical coherence tomography angiography (OCT-A).
METHODS: Nineteen patients with unilateral non-infectious retrobulbar neuritis were included in the study. The contralateral eyes of each patient were served as controls. OCT-A scans of the optic discs were performed in a 4.5 × 4.5 mm rectangular area, while macular OCT-A scans were performed in a 6 × 6 mm rectangular area. Various parameters, including radial peripapillary capillary (RPC) density, peripapillary retinal nerve fibre layer (pRNFL) thickness, cup volume, rim area, disc area, cup-to-disc (c/d) area ratio, and vertical and horizontal c/d ratios were automatically obtained using the instrument software. The density for superficial capillary plexus (SCP) and deep capillary plexus (DCP) were assessed using macular OCT-A. Parapapillary choroidal microvascular (PPCMv) density was calculated using MATLAB software.
RESULTS: Parafoveal inferior, perifoveal total and inferior SCP densities were significantly decreased in eyes with optic neuritis when compared with contralateral control eyes in OCT-A measurements (respectively, p = 0.027, p = 0.041, p = 0.045). The axial lengths, (p = 0.72), vertical and horizontal cup-disc ratios, and disc area, cup-disc areas, cup volumes, and pRNFL thicknesses between the groups were similar (for each, p>0.05).
CONCLUSIONS: This study demonstrated for the first time that patients with retrobulbar optic neuritis had decreased SCP densities, though it did not cause any changes in PPCMv density.
METHODS: Nineteen patients with unilateral non-infectious retrobulbar neuritis were included in the study. The contralateral eyes of each patient were served as controls. OCT-A scans of the optic discs were performed in a 4.5 × 4.5 mm rectangular area, while macular OCT-A scans were performed in a 6 × 6 mm rectangular area. Various parameters, including radial peripapillary capillary (RPC) density, peripapillary retinal nerve fibre layer (pRNFL) thickness, cup volume, rim area, disc area, cup-to-disc (c/d) area ratio, and vertical and horizontal c/d ratios were automatically obtained using the instrument software. The density for superficial capillary plexus (SCP) and deep capillary plexus (DCP) were assessed using macular OCT-A. Parapapillary choroidal microvascular (PPCMv) density was calculated using MATLAB software.
RESULTS: Parafoveal inferior, perifoveal total and inferior SCP densities were significantly decreased in eyes with optic neuritis when compared with contralateral control eyes in OCT-A measurements (respectively, p = 0.027, p = 0.041, p = 0.045). The axial lengths, (p = 0.72), vertical and horizontal cup-disc ratios, and disc area, cup-disc areas, cup volumes, and pRNFL thicknesses between the groups were similar (for each, p>0.05).
CONCLUSIONS: This study demonstrated for the first time that patients with retrobulbar optic neuritis had decreased SCP densities, though it did not cause any changes in PPCMv density.
摘要：
目的：使用光学相干断层扫描血管造影（OCT-A）比较球后视神经炎视盘的浅表和深层血管特征。
方法：本研究纳入了19例单侧非感染性球后神经炎患者。每个患者的对侧眼睛作为对照。在4.5×4.5mm的矩形区域中进行光学盘的OCT-A扫描,而黄斑OCT-A扫描在6×6mm的矩形区域进行。各种参数，包括径向乳头周围毛细血管（RPC）密度，乳头周围视网膜神经纤维层（pRNFL）厚度，杯子体积,边缘区域,光盘面积,杯盘面积比（c/d），使用仪器软件自动获得垂直和水平c/d比。使用黄斑OCT-A评估浅表毛细血管丛（SCP）和深层毛细血管丛（DCP）的密度。使用MATLAB软件计算旁毛细血管脉络膜微血管(PPCMv)密度。
结果：下凹，在OCT-A测量中，与对侧对照眼相比，患有视神经炎的眼的中央凹总和下SCP密度显着降低（分别为，p=0.027,p=0.041,p=0.045)。轴向长度，（p=0.72），垂直和水平杯盘比，和光盘区，杯盘区域,杯子体积,两组之间的pRNFL厚度相似(每组，p>0.05)。
结论：这项研究首次证明球后视神经炎患者的SCP密度降低，尽管它没有引起PPCMv密度的任何变化。
方法：本研究纳入了19例单侧非感染性球后神经炎患者。每个患者的对侧眼睛作为对照。在4.5×4.5mm的矩形区域中进行光学盘的OCT-A扫描,而黄斑OCT-A扫描在6×6mm的矩形区域进行。各种参数，包括径向乳头周围毛细血管（RPC）密度，乳头周围视网膜神经纤维层（pRNFL）厚度，杯子体积,边缘区域,光盘面积,杯盘面积比（c/d），使用仪器软件自动获得垂直和水平c/d比。使用黄斑OCT-A评估浅表毛细血管丛（SCP）和深层毛细血管丛（DCP）的密度。使用MATLAB软件计算旁毛细血管脉络膜微血管(PPCMv)密度。
结果：下凹，在OCT-A测量中，与对侧对照眼相比，患有视神经炎的眼的中央凹总和下SCP密度显着降低（分别为，p=0.027,p=0.041,p=0.045)。轴向长度，（p=0.72），垂直和水平杯盘比，和光盘区，杯盘区域,杯子体积,两组之间的pRNFL厚度相似(每组，p>0.05)。
结论：这项研究首次证明球后视神经炎患者的SCP密度降低，尽管它没有引起PPCMv密度的任何变化。
