PDF(Pubmed)
Abstract：
The primary reason for the failure of malaria vector control across endemic regions is the widespread insecticide resistance observed in Anopheles vectors. The most dominant African vectors of malaria parasites are Anopheles gambiae and Anopheles funestus mosquitoes. These species often exhibit divergent behaviours and adaptive changes underscoring the importance of deploying active and effective measures in their control. Unlike An. gambiae, An. funestus mosquitoes are poorly studied in Benin Republic. However, recent reports indicated that An. funestus can adapt and colonize various ecological niches owing to its resistance against insecticides and adaptation to changing breeding habitats. Unfortunately, scientific investigations on the contribution of An. funestus to malaria transmission, their susceptibility to insecticide and resistance mechanism developed are currently insufficient for the design of better control strategies. In an attempt to gather valuable information on An. funestus, the present review examines the progress made on this malaria vector species in Benin Republic and highlights future research perspectives on insecticide resistance profiles and related mechanisms, as well as new potential control strategies against An. funestus. Literature analysis revealed that An. funestus is distributed all over the country, although present in low density compared to other dominant malaria vectors. Interestingly, An. funestus is being found in abundance during the dry seasons, suggesting an adaptation to desiccation. Among the An. funestus group, only An. funestus sensu stricto (s.s.) and Anopheles leesoni were found in the country with An. funestus s.s. being the most abundant species. Furthermore, An. funestus s.s. is the only one species in the group contributing to malaria transmission and have adapted biting times that allow them to bite at dawn. In addition, across the country, An. funestus were found resistant to pyrethroid insecticides used for bed nets impregnation and also resistant to bendiocarb which is currently being introduced in indoor residual spraying formulation in malaria endemic regions. All these findings highlight the challenges faced in controlling this malaria vector. Therefore, advancing the knowledge of vectorial competence of An. funestus, understanding the dynamics of insecticide resistance in this malaria vector, and exploring alternative vector control measures, are critical for sustainable malaria control efforts in Benin Republic.
摘要：
疟疾病媒控制在流行地区失败的主要原因是在按蚊病媒中观察到的广泛的杀虫剂抗性。疟疾寄生虫最主要的非洲媒介是冈比亚按蚊和按蚊。这些物种通常表现出不同的行为和适应性变化，强调了在控制它们时采取积极有效措施的重要性。不像An.冈比亚,A.贝宁共和国对funestus蚊子的研究很少。然而,最近的报道表明，安。funestus由于对杀虫剂的抵抗力和适应不断变化的繁殖栖息地，可以适应和定居各种生态位。不幸的是,对An贡献的科学研究。疟疾传播的Funestus，它们对杀虫剂的敏感性和抗性机制的开发目前不足以设计更好的控制策略。试图收集关于An的有价值的信息。funestus,本审查审查了贝宁共和国在这种疟疾病媒物种方面取得的进展，并强调了未来关于杀虫剂抗性概况和相关机制的研究观点，以及针对An的新的潜在控制策略。funestus.文献分析表明，安。funestus分布在全国各地，尽管与其他主要疟疾媒介相比，密度较低。有趣的是,A.在干旱季节发现了大量的funestus，表明适应干燥。在An中。Funestus集团,只有一个。在该国与安一起发现了funestussensustricto（s.s.）和leesoni按蚊。funestuss.s.是最丰富的物种。此外，A.funestuss.s.是该组中唯一一个导致疟疾传播的物种，并且适应了叮咬时间，使它们能够在黎明时叮咬。此外,全国各地,A.发现funestus对用于蚊帐浸渍的拟除虫菊酯杀虫剂具有抗性，并且对目前在疟疾流行地区的室内残留喷洒制剂中引入的苯迪奥布也具有抗性。所有这些发现都突出了控制这种疟疾媒介所面临的挑战。因此,推进An的矢量能力知识。funestus,了解这种疟疾媒介中杀虫剂抗性的动态，探索替代病媒控制措施，对于贝宁共和国的可持续疟疾控制工作至关重要。
