Abstract：
Although many efforts have been made to understand the pathophysiological mechanisms of COVID-19, critical gaps remain to be explored. This study aimed to investigate potential alterations in adipokine levels (specifically adiponectin, leptin, and resistin) among individuals with COVID-19. Within this population, we further assessed the association between these markers with both, body mass index (BMI) and psychiatric symptoms. This cross-sectional study included an age- and sex-matched sample of adults with COVID-19 (cases) and without COVID-19 (controls). We evaluated the severity of psychiatric symptoms, BMI, and adipokines. Individuals with COVID-19 presented greater BMI, stress levels, and leptin levels when compared to controls. Leptin levels were greater in individuals with moderate/severe COVID-19 as compared to individuals with COVID-19 who were asymptomatic or having mild symptoms. Leptin levels were positively correlated with BMI, severity of depressive and anxiety symptoms, and stress levels in the total sample. Leptin levels were also positively correlated with BMI, severity of anxiety symptoms, and stress levels in controls. In cases, there was a positive correlation between adiponectin and the severity of depressive symptoms and stress levels and leptin/resistin with BMI. A linear regression model revealed that BMI, severity of anxiety symptoms, and the diagnosis of COVID-19 are independently associated with increased leptin levels. Thus, leptin levels seem to be impacted by the COVID-19 infection, anxiety, and BMI.
摘要：
尽管已经做出了许多努力来了解COVID-19的病理生理机制，但关键的差距仍有待探索。本研究旨在调查脂肪因子水平的潜在变化(特别是脂联素，瘦素,和抵抗素）在COVID-19患者中。在这个群体中,我们进一步评估了这些标记之间的关联，体重指数（BMI）和精神症状。这项横断面研究包括年龄和性别匹配的患有COVID-19（病例）和没有COVID-19（对照）的成年人样本。我们评估了精神症状的严重程度，BMI,和脂肪因子。COVID-19患者的BMI更高，应力水平，与对照组相比，瘦素水平。与无症状或症状轻微的COVID-19患者相比，中度/重度COVID-19患者的瘦素水平更高。瘦素水平与BMI呈正相关,抑郁和焦虑症状的严重程度，和总样本中的应力水平。瘦素水平也与BMI呈正相关,严重的焦虑症状，和控制中的压力水平。在案例中,脂联素与抑郁症状严重程度和应激水平及瘦素/抵抗素与BMI呈正相关。线性回归模型显示，BMI，严重的焦虑症状，COVID-19的诊断与瘦素水平升高独立相关。因此，瘦素水平似乎受到COVID-19感染的影响，焦虑,BMI。
