PDF(Pubmed)
Abstract：
Priapism is a painful and emergent side effect that has been linked to some antipsychotics and other psychiatric medications, most often trazodone. This is thought to be due to some level of alpha-1 adrenergic blockade by these medications. Aripiprazole is an atypical antipsychotic with notably weak alpha-1 adrenergic antagonism. Thus, we report on a unique case of aripiprazole-induced priapism in a patient with schizophrenia and recurrent episodes of antipsychotic-induced priapism. This study offers insight into the potential mechanism of aripiprazole-induced priapism and offers alternative medications, such as olanzapine and lumateperone, to treat the patient\'s ongoing psychotic disorder.
摘要：
阴茎异常勃起是一种痛苦和紧急的副作用，与一些抗精神病药物和其他精神病药物有关，最常见的是曲唑酮。这被认为是由于这些药物对α-1肾上腺素能的某种程度的阻滞。阿立哌唑是一种非典型抗精神病药，具有明显弱的α-1肾上腺素能拮抗作用。因此，我们报道了一例精神分裂症患者阿立哌唑诱导的阴茎异常勃起和抗精神病药物诱导的复发性阴茎异常勃起的独特病例.这项研究提供了深入了解阿立哌唑诱导的阴茎异常勃起的潜在机制，并提供了替代药物，如奥氮平和鲁马佩隆，来治疗病人正在进行的精神病.
