Abstract：
Glioma is a significant healthcare burden; nevertheless, the particular genetic regulatory mechanism underpinning its onset and progression is still unknown. Recent research has focused in large part on trying to determine the underlying molecular pathways that contribute to the malignancy of this disease because of the difficulties in treating it. Many tumors have been linked to changes in the expression of microRNAs (miRNAs). miRNAs play a critical role in cancer development by controlling a wide variety of targets and signaling cascades. A rising body of evidence emphasizes WNT pathway dysregulation in glioma, despite the fact that it is dysregulated in many malignancies. Here, we give a detailed analysis of the roles played by miRNAs in the WNT pathway by glioma. We also demonstrate how the WNT pathway cooperates with miRNAs to control a variety of functions, including cell proliferation, invasion, migration, and epithelial-mesenchymal transition.
摘要：
胶质瘤是一个巨大的医疗保健负担;然而，其发病和进展的具体基因调控机制尚不清楚。最近的研究在很大程度上集中在试图确定导致这种疾病恶性的潜在分子途径上，因为它的治疗困难。许多肿瘤与microRNAs（miRNAs）表达的变化有关。miRNA通过控制多种靶标和信号级联在癌症发展中发挥关键作用。越来越多的证据强调神经胶质瘤中的WNT通路失调，尽管它在许多恶性肿瘤中失调。这里,我们详细分析了miRNAs在胶质瘤WNT通路中的作用。我们还展示了WNT通路如何与miRNAs合作来控制各种功能，包括细胞增殖，入侵,迁移,和上皮-间质转化。
