PDF(Pubmed)
Abstract：
Many women with spinal muscular atrophy (SMA) types II, III, and IV reach fertile age, and some of them may consider pregnancy. However, limited data are available about the potential effects of pregnancy on the course of SMA and the outcomes of pregnancies in these patients. Furthermore, the use of several disease-modifying therapies for the treatment of all types of SMA is expected to increase the number of female SMA patients considering pregnancy in the coming years. The aim of this report is to provide clinicians with an overview of the patients in our cohort who have experienced pregnancies. We conducted a retrospective analysis on these women, through the administration of a questionnaire, which investigated how they experienced the different stages of the pregnancy. Ten patients (3 SMAII; 7 SMA III) participated in the survey; 40% had pregnancies for a total of nine, six of which were term-pregnancies. The mean age of first pregnancy was 32.5 ± 7.8 years for SMA II patients, and 30.5 ± 2.1 years for SMA III. All pregnancies ended in cesarean sections. Interestingly, the sitters had more frequent complications in pre-term labor and delivery, but the newborns were all healthy. This report shows that a successful pregnancy is possible in female patients with SMA. However, the ideal approach should involve a standardized multidisciplinary team capable of effectively addressing every possible scenario. For this reason, it is critically important that clinicians working with SMA patients gain more in-dept knowledge about this topic.
摘要：
许多患有脊髓性肌萎缩症（SMA）II型的女性，III,IV达到肥沃的年龄，他们中的一些人可能会考虑怀孕。然而,关于这些患者妊娠对SMA病程和妊娠结局的潜在影响的数据有限.此外，在所有类型的SMA的治疗中使用几种疾病改善疗法预计将增加未来几年考虑怀孕的女性SMA患者的数量.本报告的目的是为临床医生提供我们队列中经历过怀孕的患者的概述。我们对这些女性进行了回顾性分析，通过问卷的管理，调查了他们是如何经历怀孕的不同阶段的。10名患者（3名SMAII；7名SMAIII）参加了调查；40％的人怀孕了，共有9名，其中6例是足月妊娠。SMAII患者首次妊娠的平均年龄为32.5±7.8岁，SMAIII为30.5±2.1年。所有妊娠均以剖宫产结束。有趣的是,保姆在早产和分娩时出现更频繁的并发症，但是新生儿都很健康。该报告表明，SMA女性患者可能成功怀孕。然而,理想的方法应该包括一个标准化的多学科团队，能够有效地解决所有可能的情况。出于这个原因,与SMA患者一起工作的临床医生获得有关该主题的更多深入知识至关重要。
