PDF(Pubmed)
Abstract：
BACKGROUND: Acute lymphoblastic leukemia is the most common childhood cancer, with an 80% frequency in children between 1 and 10 years old. The outcome and prognosis of acute lymphoblastic leukemia in children depends on various factors, such as age, clinical and biological features, and cytogenetic factors.
METHODS: We report the case of a pediatric patient, a 4-year-old Moroccan female who was referred to the Hematology and Oncology Department of 20 August 1953 Hospital in Casablanca and diagnosed with B-cell acute lymphoblastic leukemia associated with a rare genetic chromosomal abnormality.
CONCLUSIONS: Translocation (1;4)(p21;p15) is a relatively rare chromosomal abnormality found in human leukemia and was never described isolated in pediatric B-cell acute lymphoblastic leukemia patients. It showed a good evolution by complete remission and recovery of this patient after receiving all chemotherapy and after 8 years of follow-up.
METHODS: We report the case of a pediatric patient, a 4-year-old Moroccan female who was referred to the Hematology and Oncology Department of 20 August 1953 Hospital in Casablanca and diagnosed with B-cell acute lymphoblastic leukemia associated with a rare genetic chromosomal abnormality.
CONCLUSIONS: Translocation (1;4)(p21;p15) is a relatively rare chromosomal abnormality found in human leukemia and was never described isolated in pediatric B-cell acute lymphoblastic leukemia patients. It showed a good evolution by complete remission and recovery of this patient after receiving all chemotherapy and after 8 years of follow-up.
摘要：
背景：急性淋巴细胞白血病是最常见的儿童癌症，在1至10岁的儿童中频率为80％。儿童急性淋巴细胞白血病的转归和预后取决于多种因素,比如年龄,临床和生物学特征，和细胞遗传学因素。
方法：我们报告一例儿科患者，一名4岁的摩洛哥女性,1953年8月20日被转诊至卡萨布兰卡医院血液和肿瘤科,并被诊断为与罕见遗传染色体异常相关的B细胞急性淋巴细胞白血病.
结论：易位（1;4）（p21;p15）是人类白血病中发现的相对罕见的染色体异常，从未在小儿B细胞急性淋巴细胞白血病患者中发现过。在接受所有化疗和8年随访后，该患者的完全缓解和恢复显示出良好的进展。
方法：我们报告一例儿科患者，一名4岁的摩洛哥女性,1953年8月20日被转诊至卡萨布兰卡医院血液和肿瘤科,并被诊断为与罕见遗传染色体异常相关的B细胞急性淋巴细胞白血病.
结论：易位（1;4）（p21;p15）是人类白血病中发现的相对罕见的染色体异常，从未在小儿B细胞急性淋巴细胞白血病患者中发现过。在接受所有化疗和8年随访后，该患者的完全缓解和恢复显示出良好的进展。
