METHODS: We report the case of a pediatric patient, a 4-year-old Moroccan female who was referred to the Hematology and Oncology Department of 20 August 1953 Hospital in Casablanca and diagnosed with B-cell acute lymphoblastic leukemia associated with a rare genetic chromosomal abnormality.
CONCLUSIONS: Translocation (1;4)(p21;p15) is a relatively rare chromosomal abnormality found in human leukemia and was never described isolated in pediatric B-cell acute lymphoblastic leukemia patients. It showed a good evolution by complete remission and recovery of this patient after receiving all chemotherapy and after 8 years of follow-up.
方法:我们报告一例儿科患者,一名4岁的摩洛哥女性,1953年8月20日被转诊至卡萨布兰卡医院血液和肿瘤科,并被诊断为与罕见遗传染色体异常相关的B细胞急性淋巴细胞白血病.
结论:易位(1;4)(p21;p15)是人类白血病中发现的相对罕见的染色体异常,从未在小儿B细胞急性淋巴细胞白血病患者中发现过。在接受所有化疗和8年随访后,该患者的完全缓解和恢复显示出良好的进展。