{Reference Type}: Case Reports
{Title}: t(1;4) translocation in a child with acute lymphoblastic leukemia: a case report.
{Author}: El Mahdaoui C;Hda N;Oukkache B;Dehbi H;Khoubila N;Madani A;Cherkaoui S;
{Journal}: J Med Case Rep
{Volume}: 17
{Issue}: 1
{Year}: 2023 Dec 12
暂无{DOI}: 10.1186/s13256-023-04270-9
{Abstract}: <B>BACKGROUND: </B>Acute lymphoblastic leukemia is the most common childhood cancer, with an 80% frequency in children between 1 and 10 years old. The outcome and prognosis of acute lymphoblastic leukemia in children depends on various factors, such as age, clinical and biological features, and cytogenetic factors.<BR><B>METHODS: </B>We report the case of a pediatric patient, a 4-year-old Moroccan female who was referred to the Hematology and Oncology Department of 20 August 1953 Hospital in Casablanca and diagnosed with B-cell acute lymphoblastic leukemia associated with a rare genetic chromosomal abnormality.<BR><B>CONCLUSIONS: </B>Translocation (1;4)(p21;p15) is a relatively rare chromosomal abnormality found in human leukemia and was never described isolated in pediatric B-cell acute lymphoblastic leukemia patients. It showed a good evolution by complete remission and recovery of this patient after receiving all chemotherapy and after 8 years of follow-up.