Abstract：
Delays in influenza vaccine delivery and administration can hinder vaccine coverage and protection. This study examines the differentials in distributing and administering adjuvanted trivalent (aTIV) and quadrivalent influenza vaccines (aQIV) to older adults in Italy\'s primary care setting and its potential impact on hospitalization risk over 5 epidemic seasons.
Using a primary care database, individuals aged ≥ 65 years were selected. The proportion of vaccine distribution to regional authorities and subsequent administration by GPs was estimated using census data. Using quantile (median) regression, we examined the relationship between velocities of vaccine distribution and administration (doses/week) and the incidence of hospitalizations.
Over the 5 influenza seasons, the velocity of distribution and administration of aTIV/aQIV ranged 341-833 and 152-270 median doses/week; no trend was yielded for the difference between these velocities (p = 0.189) or vaccine coverage (p = 0.142). An association was observed for each differential dose/week between distributed and administered vaccines and all-cause hospitalizations with a 10% increase in 2017-2018, 54% in 2018-2019, and 12% in 2020-2021 season.
These findings highlight the importance of minimizing the time lapse between vaccine distribution and administration to mitigate the impact of influenza and address factors that contribute to vaccination barriers.
Using a primary care database, individuals aged ≥ 65 years were selected. The proportion of vaccine distribution to regional authorities and subsequent administration by GPs was estimated using census data. Using quantile (median) regression, we examined the relationship between velocities of vaccine distribution and administration (doses/week) and the incidence of hospitalizations.
Over the 5 influenza seasons, the velocity of distribution and administration of aTIV/aQIV ranged 341-833 and 152-270 median doses/week; no trend was yielded for the difference between these velocities (p = 0.189) or vaccine coverage (p = 0.142). An association was observed for each differential dose/week between distributed and administered vaccines and all-cause hospitalizations with a 10% increase in 2017-2018, 54% in 2018-2019, and 12% in 2020-2021 season.
These findings highlight the importance of minimizing the time lapse between vaccine distribution and administration to mitigate the impact of influenza and address factors that contribute to vaccination barriers.
摘要：
■流感疫苗递送和施用的延迟会阻碍疫苗的覆盖和保护。这项研究探讨了在意大利初级保健机构中，向老年人分发和施用佐剂三价（aTIV）和四价流感疫苗（aQIV）的差异，及其对5个流行季节住院风险的潜在影响。
■使用初级保健数据库，选择年龄≥65岁的个体.使用人口普查数据估算了疫苗分配给地区当局以及随后由全科医生管理的比例。使用分位数(中位数)回归，我们研究了疫苗分发和给药速度(剂量/周)与住院发生率之间的关系.
■在5个流感季节，aTIV/aQIV的分布和给药速度范围为341-833和152-270中位剂量/周;这些速度(p=0.189)或疫苗覆盖率(p=0.142)之间的差异没有出现趋势.观察到分布式和给药疫苗与全因住院之间的每个剂量/周的相关性，2017-2018年增加10％，2018-2019年增加54％，2020-2021年增加12％。
■这些发现强调了将疫苗分发和给药之间的时间间隔最小化以减轻流感的影响和解决导致疫苗接种障碍的因素的重要性。
■使用初级保健数据库，选择年龄≥65岁的个体.使用人口普查数据估算了疫苗分配给地区当局以及随后由全科医生管理的比例。使用分位数(中位数)回归，我们研究了疫苗分发和给药速度(剂量/周)与住院发生率之间的关系.
■在5个流感季节，aTIV/aQIV的分布和给药速度范围为341-833和152-270中位剂量/周;这些速度(p=0.189)或疫苗覆盖率(p=0.142)之间的差异没有出现趋势.观察到分布式和给药疫苗与全因住院之间的每个剂量/周的相关性，2017-2018年增加10％，2018-2019年增加54％，2020-2021年增加12％。
■这些发现强调了将疫苗分发和给药之间的时间间隔最小化以减轻流感的影响和解决导致疫苗接种障碍的因素的重要性。
