PDF(Pubmed)
Abstract：
As the global population ages, the prevalence of neurodegenerative diseases is surging. These disorders have a multifaceted pathogenesis, entwined with genetic and environmental factors. Emerging research underscores the profound influence of diet on the development and progression of health conditions. Intermittent fasting (IF), a dietary pattern that is increasingly embraced and recommended, has demonstrated potential in improving neurophysiological functions and mitigating pathological injuries with few adverse effects. Although the precise mechanisms of IF\'s beneficial impact are not yet completely understood, gut microbiota and their metabolites are believed to be pivotal in mediating these effects. This review endeavors to thoroughly examine current studies on the shifts in gut microbiota and metabolite profiles prompted by IF, and their possible consequences for neural health. It also highlights the significance of dietary strategies as a clinical consideration for those with neurological conditions.
摘要：
随着全球人口老龄化,神经退行性疾病的患病率正在激增。这些疾病有多方面的发病机制,与遗传和环境因素交织在一起。新兴的研究强调了饮食对健康状况的发展和进展的深远影响。间歇性禁食（IF），一种越来越被接受和推荐的饮食模式，已证明在改善神经生理功能和减轻病理损伤方面具有潜力，而不良反应很少。虽然IF的有益影响的确切机制尚未完全了解，肠道微生物群及其代谢物被认为是介导这些作用的关键。这篇综述试图彻底检查当前关于由IF引起的肠道微生物群和代谢物谱变化的研究，以及它们对神经健康的可能后果。它还强调了饮食策略作为神经系统疾病患者的临床考虑的重要性。
