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Abstract：
The present study aimed to compare retinal sensitivity (RS) at each stage and to evaluate the relationship between RS and fundus autofluorescence (FAF) pattern in adult-onset foveomacular vitelliform dystrophy (AOFVD). We retrospectively reviewed 17 eyes of 13 patients with AOFVD. In addition to best-corrected visual acuity (VA), RS within the affected lesion and optical coherence tomography (OCT) measurements were carried out in each participant. All the examined eyes were classified into 4 stages and 3 FAF patterns. RS was superimposed on OCT fundus image and RS within the affected lesion was calculated in each eye. The relationships between visual functions (VA and RS within the affected lesion) and stages and also FAF patterns were analyzed using the linear mixed model. As a result, RS within the affected lesion was significantly associated with FAF pattern, but not with stage. In contrast, VA was correlated with neither stages nor FAF patterns. Our current result suggested that RS within the affected lesion was related to FAF patterns but this was not the case with VA in eyes with AOFVD, demonstrating the usefulness of measuring RS, not only VA, to comprehend the disease status in AOFVD.
摘要：
本研究旨在比较每个阶段的视网膜敏感性（RS），并评估成人发作的中央孔卵黄样营养不良（AOFVD）中RS与眼底自发荧光（FAF）模式之间的关系。我们回顾性分析了13例AOFVD患者的17只眼。除了最佳矫正视力（VA），在每个参与者中进行受影响病变内的RS和光学相干断层扫描（OCT）测量。所有检查的眼睛分为4个阶段和3个FAF模式。将RS叠加在OCT眼底图像上，并在每只眼睛中计算受影响病变内的RS。使用线性混合模型分析了视觉功能（受影响病变内的VA和RS）与分期以及FAF模式之间的关系。因此,受累病灶内的RS与FAF模式显著相关，但不是舞台。相比之下,VA与分期和FAF模式均不相关。我们目前的结果表明，受累病变内的RS与FAF模式有关，但AOFVD眼中的VA情况并非如此，证明了测量RS的有用性，不仅是VA,了解AOFVD的疾病状况。
