Abstract：
High-intensity focused ultrasound (HIFU) has emerged as a promising uterus-sparing and possibly fertility-sparing treatment modality for women with adenomyosis, especially those who desire to conceive. We conducted this systematic review and performed a meta-analysis on clinical studies aimed to improve reproduction in women with adenomyosis. After extensive search of PubMed and CNKI, we identified 10 studies published in English and Chinese involving a total of 557 patients with adenomyosis who desired to conceive after HIFU treatment. We found a pooled estimate of pregnancy rate of 53.4% and of the live birth rate of 35.2%, and there was a substantial heterogeneity among these studies. While there is a potential for HIFU treatment to improve fertility for patients with adenomyosis who desired to conceive, such evidence is very weak as of now. Comparative studies with much higher methodological rigor, preferably randomized clinical trials, are badly needed to further illuminate this issue.
摘要：
高强度聚焦超声（HIFU）已成为子宫腺肌病女性的一种有希望的保留子宫和可能保留生育能力的治疗方式。尤其是那些渴望怀孕的人。我们进行了这项系统评价，并对旨在改善子宫腺肌病女性生殖的临床研究进行了荟萃分析。经过对PubMed和CNKI的广泛搜索，我们确定了10项英文和中文发表的研究,共557例子宫腺肌病患者在HIFU治疗后希望怀孕.我们发现合并估计的怀孕率为53.4％，活产率为35.2％，这些研究之间存在很大的异质性。虽然HIFU治疗有可能改善想要怀孕的子宫腺肌病患者的生育能力，到目前为止，这些证据非常薄弱。具有更高方法严谨性的比较研究，最好是随机临床试验，迫切需要进一步阐明这个问题。
