目的:探讨针刺治疗冻融胚胎移植(CET)反复种植失败(RIF)患者的疗效。
方法:在一项回顾性队列研究中,我们中心从2018年1月1日至2021年12月31日招募了所有符合条件的接受RIF的女性.根据CET前是否接受针灸治疗对患者进行分组,包括针灸组(Acu-group,55个周期)和对照组(Con-group,244个周期)。采用二元logistic回归分析,探讨针灸治疗与妊娠结局的关系。
结果:Acu组的活产率(LBR)较高[54.5%vs41.0%,分别;优势比(OR)=1.105,95%置信区间(CI)(1.029,1.187),P=0.006]和持续妊娠率(OPR)[56.4%vs43.0%,分别;OR=1.100,95%CI(1.025,1.181),P=0.008]比Con组。植入率无显著组间差异[OR=1.070,95%CI(0.996,1.149),P=0.064],临床妊娠[OR=1.065,95%CI(0.997,1.138),P=0.061],生化妊娠[OR=1.002,95%CI(0.903,1.112),P=0.967],或流产[OR=0.778,95%CI(0.551,1.099),P=0.155]。两组之间的围产期结局没有显着差异。
结论:针刺治疗可改善CET周期RIF患者的LBR和OPR,提示一种潜在的针灸辅助疗法可以改善RIF患者的妊娠结局。
OBJECTIVE: To explore the therapeutic efficacy of acupuncture treatment on repeated implantation failure (RIF) patients with cryo-thawed embryo transfer (CET).
METHODS: In a retrospective cohort study, all eligible women undergoing RIF were recruited in our center from January 1, 2018 to December 31, 2021. The patients were grouped by whether an acceptance of acupuncture treatment before CET, including the acupuncture group (Acu-group, 55 cycles) and control group (Con-group, 244 cycles). Data were analyzed by using binary logistic regression to explore the relationship of acupuncture treatment with pregnancy outcomes.
RESULTS: The Acu-group had higher live-birth rate (LBR) [54.5% vs41.0%, respectively; odds ratio (OR) = 1.105, 95% confidence interval (CI) (1.029, 1.187), P =0.006] and ongoing pregnancy rate (OPR) [56.4% vs43.0%, respectively; OR= 1.100, 95% CI(1.025, 1.181), P =0.008] than the Con-group. There were no significant between-group differences in the rates of implantation [OR= 1.070, 95% CI(0.996, 1.149), P =0.064], clinical pregnancy [OR= 1.065, 95% CI(0.997, 1.138), P =0.061], biochemical pregnancy [OR= 1.002, 95% CI(0.903, 1.112), P =0.967], or miscarriage [OR= 0.778, 95% CI(0.551, 1.099), P =0.155]. Perinatal outcomes did not differ significantly between the two groups.
CONCLUSIONS: Acupuncture treatment could improve the LBR and OPR in RIF patients with CET cycles, suggesting a potential adjuvant therapy of acupuncture to improve the pregnancy outcomes in RIF patients.