PDF(Pubmed)
Abstract：
UNASSIGNED: Trisomy 18 syndrome, also known as Edwards syndrome, is a chromosomal trisomy. The syndrome has historically been considered lethal owing to its poor prognosis, and palliative care was primarily indicated for trisomy 18 neonates. Although there have been several reports on the improvement of survival outcomes in infants with trisomy 18 syndrome through neonatal intensive care, few studies have compared the impact of neonatal intensive care on survival outcomes with that of non-intensive care. Therefore, we compared the survival-related outcomes of neonates with trisomy 18 between intensive and non-intensive care.
UNASSIGNED: Seventeen infants of trisomy 18 admitted to our center between 2007 and 2019 were retrospectively studied. We divided the patients into a non-intensive group (n = 5) and an intensive group (n = 12) and evaluated their perinatal background and survival-related outcomes of the two groups.
UNASSIGNED: The 1- and 3-year survival rates were both 33% in the intensive group, which was significantly higher than that in the non-intensive group (p < 0.001). Half of the infants in the intensive care group were discharged alive, whereas in the non-intensive care group, all died during hospitalization (p = 0.049).
UNASSIGNED: Neonatal intensive care for neonates with 18 trisomy significantly improved not only survival rates but also survival-discharge rates. Our findings would be helpful in providing 18 trisomy neonates with standard neonatal intensive care when discussing medical care with their parents.
UNASSIGNED: Seventeen infants of trisomy 18 admitted to our center between 2007 and 2019 were retrospectively studied. We divided the patients into a non-intensive group (n = 5) and an intensive group (n = 12) and evaluated their perinatal background and survival-related outcomes of the two groups.
UNASSIGNED: The 1- and 3-year survival rates were both 33% in the intensive group, which was significantly higher than that in the non-intensive group (p < 0.001). Half of the infants in the intensive care group were discharged alive, whereas in the non-intensive care group, all died during hospitalization (p = 0.049).
UNASSIGNED: Neonatal intensive care for neonates with 18 trisomy significantly improved not only survival rates but also survival-discharge rates. Our findings would be helpful in providing 18 trisomy neonates with standard neonatal intensive care when discussing medical care with their parents.
摘要：
■18三体综合征，也被称为爱德华兹综合症，是染色体三体。由于预后不良，该综合征历来被认为是致命的。姑息治疗主要适用于18三体新生儿。尽管有一些关于通过新生儿重症监护改善18三体综合征婴儿的生存结果的报道，很少有研究比较新生儿重症监护与非重症监护对生存结局的影响.因此,我们比较了重症监护与非重症监护新生儿18三体综合征的生存相关结局.
■对2007年至2019年期间入住我们中心的17名18三体婴儿进行了回顾性研究。我们将患者分为非强化组（n=5）和强化组（n=12），并评估了两组的围产期背景和生存相关结局。
■强化组的1年和3年生存率均为33%，显著高于非密集组(p<0.001)。重症监护组中有一半的婴儿存活出院,而在非重症监护组中，所有患者均在住院期间死亡(p=0.049).
■对18三体新生儿的新生儿重症监护不仅显着提高了生存率，而且还提高了生存率。在与父母讨论医疗护理时，我们的发现将有助于为18名三体性新生儿提供标准的新生儿重症监护。
■对2007年至2019年期间入住我们中心的17名18三体婴儿进行了回顾性研究。我们将患者分为非强化组（n=5）和强化组（n=12），并评估了两组的围产期背景和生存相关结局。
■强化组的1年和3年生存率均为33%，显著高于非密集组(p<0.001)。重症监护组中有一半的婴儿存活出院,而在非重症监护组中，所有患者均在住院期间死亡(p=0.049).
■对18三体新生儿的新生儿重症监护不仅显着提高了生存率，而且还提高了生存率。在与父母讨论医疗护理时，我们的发现将有助于为18名三体性新生儿提供标准的新生儿重症监护。
