Abstract：
Stroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation (VNS) is a promising immunomodulatory method that has shown positive effects in stroke treatment, including neuroprotection, anti-apoptosis, anti-inflammation, antioxidation, reduced infarct volume, improved neurological scores, and promotion of M2 microglial polarization. In this review, we summarize the current knowledge about the vagus nerve\'s immunomodulatory effects through the cholinergic anti-inflammatory pathway (CAP) and provide a comprehensive assessment of the available experimental literature focusing on the use of VNS in stroke treatment.
摘要：
中风是一种具有高发病率和死亡率的破坏性脑血管病理。炎症在中风的病理生理学中起重要作用。迷走神经刺激（VNS）是一种有前途的免疫调节方法，在中风治疗中显示出积极的效果，包括神经保护,抗凋亡，抗炎，抗氧化，梗死体积减少,改善神经学评分,M2促进小胶质细胞极化。在这次审查中,我们总结了目前有关迷走神经通过胆碱能抗炎通路(CAP)的免疫调节作用的知识,并对现有的实验文献进行了全面评估,重点是VNS在卒中治疗中的应用.
