Abstract：
To investigate the potential relationship between common nonsteroidal anti-inflammatory drugs (NSAIDs), genetic susceptibility and all-cause dementia (ACD), Alzheimer\'s disease (AD), and vascular dementia (VD) among individuals experiencing chronic pain.
This study was based on 194,758 chronic pain participants form UK biobank with a median follow-up of 13.7 years. Participants were categorized into different NSAIDs painkiller regimen groups: No NSAIDs group, Aspirin group, Ibuprofen group, Paracetamol group, and 2-3 NSAIDs group. Cox proportional risk models were used to examine the correlation between regular NSAIDs usage and the risk of ACD, AD, and VD. In addition, we further performed subgroup analyses and sensitivity analyses.
1) Compared to the No NSAIDs group, the aspirin group (HR = 1.12, 95% CI:1.01-1.24, P < 0.05), the paracetamol group (HR = 1.15, 95% CI:1.05-1.27, P < 0.01), and the 2-3 NSAIDs group (HR = 1.2, 95% CI:1.08-1.33, P < 0.05) showed a higher risk of ACD. Furthermore, the 2-3 NSAIDs group was also associated with a higher risk of VD (HR = 1.39, 95% CI: 1.08-1.33, P < 0.05). 2) At high dementia GRS participants with chronic pain, the paracetamol group (HR = 1.2, 95% CI: 1.03-1.43, P < 0.05) and the NSAIDs group (HR = 1.3, 95% CI: 1.07-1.59, P < 0.05) were associated with a higher risk of ACD compared to the no painkiller group. 3) There was no significant association between ibuprofen use and higher risk of dementia.
In individuals with chronic pain, the use of aspirin and paracetamol was associated with a higher risk of ACD, whereas the use of ibuprofen was not significantly associated with a higher risk of ACD.
This study was based on 194,758 chronic pain participants form UK biobank with a median follow-up of 13.7 years. Participants were categorized into different NSAIDs painkiller regimen groups: No NSAIDs group, Aspirin group, Ibuprofen group, Paracetamol group, and 2-3 NSAIDs group. Cox proportional risk models were used to examine the correlation between regular NSAIDs usage and the risk of ACD, AD, and VD. In addition, we further performed subgroup analyses and sensitivity analyses.
1) Compared to the No NSAIDs group, the aspirin group (HR = 1.12, 95% CI:1.01-1.24, P < 0.05), the paracetamol group (HR = 1.15, 95% CI:1.05-1.27, P < 0.01), and the 2-3 NSAIDs group (HR = 1.2, 95% CI:1.08-1.33, P < 0.05) showed a higher risk of ACD. Furthermore, the 2-3 NSAIDs group was also associated with a higher risk of VD (HR = 1.39, 95% CI: 1.08-1.33, P < 0.05). 2) At high dementia GRS participants with chronic pain, the paracetamol group (HR = 1.2, 95% CI: 1.03-1.43, P < 0.05) and the NSAIDs group (HR = 1.3, 95% CI: 1.07-1.59, P < 0.05) were associated with a higher risk of ACD compared to the no painkiller group. 3) There was no significant association between ibuprofen use and higher risk of dementia.
In individuals with chronic pain, the use of aspirin and paracetamol was associated with a higher risk of ACD, whereas the use of ibuprofen was not significantly associated with a higher risk of ACD.
摘要：
目的：探讨常用非甾体抗炎药（NSAIDs）与非甾体抗炎药的潜在关系。遗传易感性和全因痴呆（ACD），阿尔茨海默病（AD），和血管性痴呆（VD）的个体经历慢性疼痛。
方法：这项研究基于英国生物库的194,758名慢性疼痛参与者，中位随访时间为13.7年。参与者分为不同的NSAIDs止痛药组：无NSAIDs组，阿司匹林组,布洛芬组,扑热息痛组,和2-3个NSAIDs组。Cox比例风险模型用于检查常规使用NSAIDs与ACD风险之间的相关性。AD,和VD。此外,我们进一步进行了亚组分析和敏感性分析.
结果：1）与无NSAIDs组相比，阿司匹林组(HR=1.12,95%CI:1.01~1.24,P<0.05),对乙酰氨基酚组（HR=1.15，95％CI：1.05-1.27，P<0.01），2-3NSAIDs组（HR=1.2，95％CI：1.08-1.33，P<0.05）显示出更高的ACD风险。此外，2-3NSAIDs组也与较高的VD风险相关(HR=1.39,95%CI:1.08-1.33,P<0.05)。2）在患有慢性疼痛的高痴呆GRS参与者中，扑热息痛组(HR=1.2,95%CI:1.03-1.43,P<0.05)和NSAIDs组(HR=1.3,95%CI:1.07-1.59,P<0.05)与无止痛药组相比,ACD风险较高.3）布洛芬的使用与痴呆症的高风险之间没有显着关联。
结论：在患有慢性疼痛的个体中，阿司匹林和扑热息痛的使用与ACD的高风险相关，而布洛芬的使用与更高的ACD风险无显著相关.
方法：这项研究基于英国生物库的194,758名慢性疼痛参与者，中位随访时间为13.7年。参与者分为不同的NSAIDs止痛药组：无NSAIDs组，阿司匹林组,布洛芬组,扑热息痛组,和2-3个NSAIDs组。Cox比例风险模型用于检查常规使用NSAIDs与ACD风险之间的相关性。AD,和VD。此外,我们进一步进行了亚组分析和敏感性分析.
结果：1）与无NSAIDs组相比，阿司匹林组(HR=1.12,95%CI:1.01~1.24,P<0.05),对乙酰氨基酚组（HR=1.15，95％CI：1.05-1.27，P<0.01），2-3NSAIDs组（HR=1.2，95％CI：1.08-1.33，P<0.05）显示出更高的ACD风险。此外，2-3NSAIDs组也与较高的VD风险相关(HR=1.39,95%CI:1.08-1.33,P<0.05)。2）在患有慢性疼痛的高痴呆GRS参与者中，扑热息痛组(HR=1.2,95%CI:1.03-1.43,P<0.05)和NSAIDs组(HR=1.3,95%CI:1.07-1.59,P<0.05)与无止痛药组相比,ACD风险较高.3）布洛芬的使用与痴呆症的高风险之间没有显着关联。
结论：在患有慢性疼痛的个体中，阿司匹林和扑热息痛的使用与ACD的高风险相关，而布洛芬的使用与更高的ACD风险无显著相关.
