METHODS: We describe a case study of an eleven-year-old male patient with myotonic dystrophy type 1 and comorbid ADHD that was treated with methylphenidate in a twice daily regime (0.60 mg/kg/day). Positive effects on learning and cognition were reported by the parents and teachers. No negative side effects were reported. Sequential neuropsychological assessments before and 45 minutes after methylphenidate intake were conducted to quantify the cognitive effects of methylphenidate treatment. Significant improvements in regulation of attention were behaviorally observed and were quantified using eye tracking technology.
CONCLUSIONS: We conclude that methylphenidate may be an effective treatment for ADHD-related cognitive deficits and learning difficulties in children with myotonic dystrophy type 1 which merits further research.
方法:我们描述了一个11岁男性强直性肌营养不良1型和合并ADHD患者的案例研究,该患者每天两次使用哌醋甲酯治疗(0.60mg/kg/天)。父母和老师报告了对学习和认知的积极影响。没有负面副作用的报道。在摄入哌醋甲酯之前和之后45分钟进行序贯神经心理学评估以量化哌醋甲酯治疗的认知效果。在行为上观察到注意力调节的显着改善,并使用眼动追踪技术进行了量化。
结论:我们得出结论,哌醋甲酯可能是1型强直性肌营养不良儿童ADHD相关认知缺陷和学习困难的有效治疗方法,值得进一步研究。