PDF(Pubmed)
Abstract：
Regular physical activity and the use of nutritional supplements, including antioxidants, are recognized as efficacious approaches for the prevention and mitigation of obesity-related complications. This study investigated the effects of 12 weeks of CrossFit training combined with astaxanthin (ASX) supplementation on some plasma adipokines in males with obesity. Sixty-eight males with obesity (BMI: 33.6 ± 1.4 kg·m-2) were randomly assigned into four groups: the control group (CG; n = 11), ASX supplementation group (SG; n = 11), CrossFit group (TG; n = 11), and training plus supplement group (TSG; n = 11). Participants underwent 12 weeks of supplementation with ASX or placebo (20 mg/day capsule daily), CrossFit training, or a combination of both interventions. Plasma levels of semaphorin 3C (SEMA3C), apelin, chemerin, omentin1, visfatin, resistin, adiponectin, leptin, vaspin, and RBP4 were measured 72 h before the first training session and after the last training session. The plasma levels of all measured adipokines were significantly altered in SG, TG, and TSG groups (p < 0.05). The reduction of resistin was significantly higher in TSG than in SG (p < 0.05). The plasma levels of omentin1 were significantly higher in both training groups of TG and TSG than SG (p < 0.05), although such a meaningful difference was not observed between both training groups (p > 0.05). Significant differences were found in the reductions of plasma levels of vaspin, visfatin, apelin, RBP4, chemerin, and SEMA3C between the SG and TSG groups (p < 0.05). The study found that a 12-week intervention using ASX supplementation and CrossFit exercises resulted in significant improvements in several adipokines among male individuals with obesity. Notably, the combined approach of supplementation and training had the most pronounced results. The findings presented in this study indicate that the supplementation of ASX and participation in CrossFit exercise have the potential to be effective therapies in mitigating complications associated with obesity and enhancing metabolic health.
摘要：
定期进行体育锻炼和使用营养补充剂，包括抗氧化剂,被认为是预防和缓解肥胖相关并发症的有效方法。这项研究调查了12周的CrossFit训练结合虾青素（ASX）补充对肥胖男性某些血浆脂肪因子的影响。68名肥胖男性（BMI：33.6±1.4kg·m-2）被随机分为四组：对照组（CG；n=11），ASX补充组（SG；n=11），CrossFit组（TG；n=11），和培训加补充组（TSG；n=11）。参与者接受了12周的ASX或安慰剂补充（每天20毫克/天的胶囊），CrossFit训练,或两种干预措施的组合。信号素3C（SEMA3C）的血浆水平，apelin,chemerin,omentin1,visfatin,抵抗素,脂联素,瘦素,vaspin,在第一次训练前72小时和最后一次训练后测量RBP4。在SG中，所有测量的脂肪因子的血浆水平都发生了显着变化，TG,和TSG组(p<0.05)。TSG中抵抗素的降低明显高于SG（p<0.05）。TG和TSG两个训练组的血浆Omentin1水平均明显高于SG（p<0.05），尽管在两个训练组之间没有观察到这种有意义的差异(p>0.05)。血浆vaspin水平的降低存在显着差异，visfatin,apelin,RBP4,chemerin,SG和TSG组之间的SEMA3C（p<0.05）。研究发现，使用ASX补充剂和CrossFit锻炼进行为期12周的干预可显著改善肥胖男性个体中的几种脂肪因子。值得注意的是,补充和培训相结合的方法取得了最显著的结果.这项研究的结果表明，补充ASX和参与CrossFit运动有可能成为减轻与肥胖相关的并发症和增强代谢健康的有效疗法。
