PDF(Pubmed)
Abstract：
BACKGROUND: Diet is one of the most important modifiable risk factors associated with cardiovascular health (CH). Research identifying dietary patterns (DPs) through data-driven analysis and reporting associations between DPs and coronary artery disease (CAD) outcomes is rather limited.
OBJECTIVE: The aim of the present report was to generate DPs through factor analysis (FA) and to examine their association with CAD risk.
METHODS: Participants (n = 1017) consisted of cases diagnosed with CAD (n = 356) and controls (n = 661) drawn from the THISEAS study. Demographic, anthropometric and lifestyle data were collected. Dietary components were generated through FA. Logistic regression analysis was performed to estimate CAD relative risks.
RESULTS: FA generated seven dietary components, explaining 53.5% of the total variation in intake. The Western-type DP showed a modest significant association with CAD risk, after controlling for confounders (OR = 1.20; 95% CI = 1.09-1.32, p < 0.001). The vegetarian-type DP was not significantly associated with the likelihood of CAD (OR = 0.95; 95% CI = 0.84-1.04, p = 0.259).
CONCLUSIONS: The Western-type DP was positively associated with CAD risk and the odds were further increased after controlling for confounders. This finding is in concordance with previously reported positive associations between Western patterns and CAD risk. Limited data exist regarding a posteriori DPs and their effect on CAD risk.
OBJECTIVE: The aim of the present report was to generate DPs through factor analysis (FA) and to examine their association with CAD risk.
METHODS: Participants (n = 1017) consisted of cases diagnosed with CAD (n = 356) and controls (n = 661) drawn from the THISEAS study. Demographic, anthropometric and lifestyle data were collected. Dietary components were generated through FA. Logistic regression analysis was performed to estimate CAD relative risks.
RESULTS: FA generated seven dietary components, explaining 53.5% of the total variation in intake. The Western-type DP showed a modest significant association with CAD risk, after controlling for confounders (OR = 1.20; 95% CI = 1.09-1.32, p < 0.001). The vegetarian-type DP was not significantly associated with the likelihood of CAD (OR = 0.95; 95% CI = 0.84-1.04, p = 0.259).
CONCLUSIONS: The Western-type DP was positively associated with CAD risk and the odds were further increased after controlling for confounders. This finding is in concordance with previously reported positive associations between Western patterns and CAD risk. Limited data exist regarding a posteriori DPs and their effect on CAD risk.
摘要：
背景：饮食是与心血管健康（CH）相关的最重要的可改变的危险因素之一。通过数据驱动分析和报告DPs与冠状动脉疾病（CAD）结果之间的关联来确定饮食模式（DPs）的研究相当有限。
目的：本报告的目的是通过因子分析（FA）生成DPs，并检查其与CAD风险的关联。
方法：参与者（n=1017）包括来自THISEAS研究的诊断为CAD的病例（n=356）和对照组（n=661）。人口统计,收集人体测量和生活方式数据.通过FA产生膳食成分。进行Logistic回归分析以估计CAD相对风险。
结果：FA产生了7种膳食成分，解释了摄入量总变化的53.5%。西方型DP显示与CAD风险有适度的显着关联，控制混杂因素后(OR=1.20；95%CI=1.09-1.32，p<0.001)。素食型DP与CAD的可能性没有显着相关（OR=0.95；95％CI=0.84-1.04，p=0.259）。
结论：Western型DP与CAD风险呈正相关，并且在控制混杂因素后，几率进一步增加。这一发现与先前报道的西方模式和CAD风险之间的正相关一致。关于后验DP及其对CAD风险的影响的数据有限。
目的：本报告的目的是通过因子分析（FA）生成DPs，并检查其与CAD风险的关联。
方法：参与者（n=1017）包括来自THISEAS研究的诊断为CAD的病例（n=356）和对照组（n=661）。人口统计,收集人体测量和生活方式数据.通过FA产生膳食成分。进行Logistic回归分析以估计CAD相对风险。
结果：FA产生了7种膳食成分，解释了摄入量总变化的53.5%。西方型DP显示与CAD风险有适度的显着关联，控制混杂因素后(OR=1.20；95%CI=1.09-1.32，p<0.001)。素食型DP与CAD的可能性没有显着相关（OR=0.95；95％CI=0.84-1.04，p=0.259）。
结论：Western型DP与CAD风险呈正相关，并且在控制混杂因素后，几率进一步增加。这一发现与先前报道的西方模式和CAD风险之间的正相关一致。关于后验DP及其对CAD风险的影响的数据有限。
