factor analysis

因子分析
  • 文章类型: Journal Article
    本研究旨在开发和验证一种仪器,基于健康信念模型的成人牙科探视行为(DVBHBM),并基于健康信念模型评估影响成年人牙科就诊行为的因素。
    这项横断面研究是在海得拉巴的277名成年人中进行的,印度。DVBHBM仪器,基于健康信念模型,被开发,已验证,并在参与者之间分配。探索性因素分析,可靠性分析,描述性分析,独立t检验,并进行了路径分析来探索结构效度,内部一致性,态度,以及变量之间的关系。
    与定期牙科就诊的参与者相比,有不适的参与者表现出更高的感知易感性(3.70±1.15)(2.84±1.26,p<0.05)。相反,定期就诊的个体表现出明显更大的感知益处(22.32±2.5),比经历不适的个体(19.76±3.36,p=0.001).与经历不适的人(12.71±4.26,p=0.001)相比,定期就诊的人的感知障碍较低(11.01±4.61)。定期就诊的参与者也比那些经历不适的人(2.91±1.03,p=0.000)更强烈地感受到不去看牙医的严重程度(3.87±0.95)。与定期就诊的患者相比,不适患者(3.34±1.06)的行动线索更为明显(2.98±1.07,p<0.05)。
    在牙科就诊中表现出不适的参与者的感知易感性明显更高,感知障碍,对牙科就诊的行动和自我效能的线索。然而,年龄等因素,性别,婚姻状况,收入,刷牙,使用牙线和烟草不会影响成年人的牙科就诊行为。
    UNASSIGNED: This study aimed to develop and validate an instrument, Dental Visiting Behavior Based on Health Belief Model among Adults (DVBHBM), and to assess factors influencing adults\' dental visiting behavior based on Health Belief Model.
    UNASSIGNED: This cross-sectional study was conducted among 277 adults in Hyderabad, India. The DVBHBM instrument, based on Health Belief Model, was developed, validated, and distributed among participants. Exploratory factor analysis, reliability analysis, descriptive analysis, independent t-tests, and path analysis were conducted to explore construct validity, internal consistency, attitudes, and relationship among variables.
    UNASSIGNED: Participants with discomfort exhibited higher perceived susceptibility (3.70 ± 1.15) compared to those with regular dental visits (2.84 ± 1.26, p < 0.05). Conversely, individuals with regular dental visits demonstrated significantly greater perceived benefits (22.32 ± 2.5) than those experiencing discomfort (19.76 ± 3.36, p = 0.001). Perceived barriers were lower among individuals with regular dental visits (11.01 ± 4.61) compared to those experiencing discomfort (12.71 ± 4.26, p = 0.001). Participants with regular dental visits also perceived the severity of not visiting a dentist (3.87 ± 0.95) more strongly than those experiencing discomfort (2.91 ± 1.03, p = 0.000). Cues to action were more pronounced in individuals with discomfort (3.34 ± 1.06) compared to those with regular dental visits (2.98 ± 1.07, p < 0.05).
    UNASSIGNED: Participants exhibiting discomfort in dental visits had significantly higher perceived susceptibility, perceived barriers, cues to action and self-efficacy towards dental visits. However, factors such as age, gender, marital status, income, brushing, flossing and tobacco use did not impact dental visiting behaviour of adults.
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  • 文章类型: Journal Article
    学校心理学家有许多角色和责任,往往导致高压力水平。Wise(1985)撰写了“学校心理学家和压力量表”(SPSI),但自出版以来,它没有实质性更新。我们开发了两项研究来解决目前正在练习学校心理学家所面临的压力源。研究1包括229个实践学校的心理学家,他们评估了SPSI项目的相关性,并列出了考虑到当前实践背景而经历的五个高度紧张的事件。基于这些结果,13个SPSI项目被删除,修订了21个SPSI项目,并增加了12个新项目。由此产生的措施,学校心理学家苦恼清单(SPDI),由33个项目和一个额外的项目解决整体压力。研究2检查了与SPDI评分结构相关的有效性证据。使用350名实习学校心理学家的样本数据,一系列探索性因素分析方法表明,存在一般的痛苦因素以及四个更具体的因素,包括繁重的工作量,学生需要,缺乏专业支持,父母和法律冲突。在(a)SPDI总量表和子量表以及(b)反映总体压力水平的度量之间,收敛关系和判别关系很明显,角色压力源,角色过载,和工作满意度。对SPDI分数的检查显示它们与年龄没有显着相关,教育水平,或按州划分的学校-心理学家与学生的比例;然而,缺乏专业支持具有统计学意义,但与多年的经验关系较弱。美国西部地区的学生需求比中西部地区的参与者压力更大。这两项研究的结果表明,使用SPDI来检查学校心理学家的一般和特定经历的痛苦是有希望的,他们揭示了整个学校心理学家的痛苦是非常高的,特别是在与繁重工作量相关的领域。进一步研究更多种族和种族不同的学校心理学家样本,将增强使用SPDI作为困扰衡量标准的信心。结果表明,迫切需要解决学校心理学家对压力和个人应对策略的结构性影响。
    School psychologists have many roles and responsibilities that often lead to high stress levels. Wise (1985) authored the School Psychologists and Stress Inventory (SPSI), but it has not been updated substantially since its publication. We developed two studies to address the stressors faced by currently practicing school psychologists. Study 1 included 229 practicing school psychologists who evaluated the relevancy of the SPSI items and who listed five highly stressful events experienced considering the current context of practice. Based on these results, 13 SPSI items were removed, 21 SPSI items were revised, and 12 new items were added. The resulting measure, the School Psychologist Distress Inventory (SPDI), consists of 33 items and an additional item addressing overall stress. Study 2 examined validity evidence associated with the SPDI score structure. Using data from a sample of 350 practicing school psychologists, a sequence of exploratory factor analytic methods indicated the presence of a general factor of distress as well as four more specific factors, including Heavy Workload, Student Needs, Lack of Professional Support, and Parental and Legal Conflicts. Convergent relations and discriminant relations were evident between (a) SPDI total and subscales and (b) measures reflecting general stress level, role stressors, role overload, and job satisfaction. Examination of SPDI scores revealed they were not significantly related to age in years, educational levels, or school-psychologist-to-student ratio by state; however, lack of professional support was statistically significantly but weakly related to years of experience. Student needs were significantly more stressful across participants in the Western region of the United States than the Midwest region. Results from these two studies suggest the promise of using the SPDI to examine general and specific experiences of school psychologists\' distress and they reveal that distress across school psychologists is remarkably high-especially in the area associated with having a heavy workload. Additional research with more racially and ethnically diverse samples of school psychologists would enhance confidence in using the SPDI as a measure of distress. Results suggest an urgent need to address structural influences on stress and personal coping strategies employed by school psychologists.
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  • 文章类型: Journal Article
    目的:行为的限制性和/或重复性表现,利益,或活动(RRB)是自闭症谱系障碍(ASD)的核心症状领域之一。当前和过去的研究表明,ASD儿童的RRB有两个“集群”:重复性感觉运动(例如,手/手指和更复杂的运动习惯)和坚持相同(例如,抵抗环境变化)的行为。当前的研究旨在通过检查临床样本中患有ASD和其他神经发育障碍(ONDD)的个体中RRB的差异来填补空白。
    方法:共有558名患者在三级护理诊所接受了ASD的综合临床评估。基于临床诊断将样品分成ASD(n=292个个体)和ONDD(n=266)组。使用自闭症诊断访谈修订(ADI-R)RRB项目得分对整个样本进行探索性因素分析,ASD组,和ONDD组。
    结果:ADI-RRRB项目的探索性因素分析表明,全样本和ASD组采用2因素解决方案。加载到两个因素的项目,包括“重复性感觉运动”和“坚持一致性”行为,与以前的文献一致。结果表明非ASD组的独特负荷模式,将项目聚类为“更高阶”(例如,限制利益)和“低级”(例如,手和手指习惯)行为。
    结论:当前研究的结果可能表明,使用RRB来指导进行ASD评估的儿童筛查,以更好地识别患有ASD风险较高的儿童。
    OBJECTIVE: Restricted and/or repetitive displays of behavior, interests, or activities (RRBs) are one of the core symptom domains of autism spectrum disorder (ASD). Current and past research indicates two \'clusters\' of RRBs in children with ASD: repetitive sensorimotor (e.g., hand/finger and more complex motor mannerisms) and insistence on sameness (e.g., resistance to changes in the environment) behaviors. The current study aims to fill a gap by examining how RRBs may diverge in individuals with ASD and with other neurodevelopmental disorders (ONDD) in a clinical sample.
    METHODS: A total of 558 individuals were seen at a tertiary care clinic for a comprehensive clinical assessment of ASD. The sample was split into ASD (n = 292 individuals) and ONDD (n = 266) groups based on clinical diagnosis. Exploratory factor analyses were conducted using Autism Diagnostic Interview-Revised (ADI-R) RRB item scores for the overall sample, the ASD group, and the ONDD group.
    RESULTS: Exploratory factor analysis of ADI-R RRB items indicated a 2-factor solution for the full sample and ASD group. Items loaded onto two factors comprised of \"Repetitive Sensorimotor\" and \"Insistence on Sameness\" behaviors, consistent with previous literature. Results demonstrated a unique loading pattern for the non-ASD group, with items clustering into \"Higher Order\" (e.g., circumscribed interests) and \"Lower Order\" (e.g., hand and finger mannerisms) behaviors.
    CONCLUSIONS: The results of the current study may point towards using RRBs to guide screening of children who are referred for an ASD evaluation to better identify children who are at higher risk of having ASD.
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  • 文章类型: Journal Article
    骨密度(BMD)是预测骨折风险和诊断骨质疏松症的重要指标。随着全球骨质疏松症患病率的上升,了解膳食模式与骨密度之间的关系对公共卫生至关重要。这项研究旨在使用国家健康与营养调查(NHANES)的数据探索成年人的各种饮食模式与BMD之间的关联。
    分析了2013年至2020年三个非连续调查周期中8,416名40岁及以上的NHANES参与者的数据。使用因子分析和聚类分析的组合来确定饮食模式。然后评估BMD测量值,并分析了与确定的饮食模式的关联,对人口变量进行了调整。
    分析确定了三种不同的饮食模式:“低蛋白高膳食纤维-维生素A-镁(LP-HDF-VitA-Mg)”“高常量营养素-胆碱-硒(HM-Cho-Se)”,和“低常量营养素-维生素D-钙(LM-VitD-Ca)”然后我们发现女人,老年人,某些种族群体的低BMD风险较高。与遵循“LM-VitD-Ca”模式的参与者相比,坚持“HM-Cho-Se”和“LP-HDF-VitA-Mg”饮食模式的参与者表现出更高的BMD。在调整人口统计学变量后,“HM-Cho-Se”模式与骨密度保持正相关,而“LM-VitD-Ca”模式与BMD或低BMD风险无显著关联。
    研究结果表明,坚持“HM-Cho-Se”饮食模式可能会降低低骨密度的风险,表明这些营养素对骨骼健康的潜在协同作用。然而,这项研究有局限性,包括因子分析中的横断面设计和潜在主观性。未来的研究应集中在涉及不同年龄段的纵向研究上,以更好地了解饮食模式与BMD之间的因果关系。尽管有这些限制,该研究强调了饮食因素对维持骨骼健康的重要性,并提出了潜在的饮食干预措施,以降低低骨密度和骨质疏松症的风险.
    UNASSIGNED: Bone mineral density (BMD) is a crucial index for predicting fracture risk and diagnosing osteoporosis. With the global rise in osteoporosis prevalence, understanding the relationship between dietary patterns and BMD is vital for public health. This study aimed to explore the association between various dietary patterns and BMD among adults using data from the National Health and Nutrition Examination Survey (NHANES).
    UNASSIGNED: Data were analyzed from 8,416 NHANES participants aged 40 years and older across three non-consecutive survey cycles from 2013 to 2020. Dietary patterns were identified using a combination of factor analysis and cluster analysis. BMD measurements were then assessed, and associations with the identified dietary patterns were analyzed, with adjustments made for demographic variables.
    UNASSIGNED: The analysis identified three distinct dietary patterns: \"Low protein-High Dietary fiber-Vitamin A-Magnesium (LP-HDF-Vit A-Mg)\", \"High macronutrient-Choline-Selenium (HM-Cho-Se)\", and \"Low macronutrient-Vitamin D-Calcium (LM-Vit D-Ca)\", and then we found that women, older adults, and certain ethnic groups were at higher risk for low BMD. Participants adhering to the \"HM-Cho-Se\" and \"LP-HDF-Vit A-Mg\" dietary patterns exhibited significantly higher BMD compared to those following the \"LM-Vit D-Ca\" pattern. After adjusting for demographic variables, the \"HM-Cho-Se\" pattern remained positively associated with BMD, while the \"LM-Vit D-Ca\" pattern showed no significant association with BMD or the risk of low BMD.
    UNASSIGNED: The findings suggest that adherence to the \"HM-Cho-Se\" dietary pattern may reduce the risk of low BMD, indicating potential synergies between these nutrients for bone health. However, the study has limitations, including the cross-sectional design and potential subjectivity in factor analysis. Future research should focus on longitudinal studies involving diverse age groups to better understand the causal relationship between dietary patterns and BMD. Despite these limitations, the study highlights the importance of dietary factors in maintaining bone health and suggests potential dietary interventions to reduce the risk of low BMD and osteoporosis.
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  • 文章类型: Journal Article
    背景:儿童经历(ACE)和父母疏离(PA)是不利事件的形式,对全球儿童产生负面影响。当前的研究是确定修订的ACEs措施,其中包括PA的筛查项目。
    方法:总共231名本科生,年龄在18至37岁之间,进行了这项分析。进行了因子分析,以确定哪些PA项目,四个人中,将与现有的ACE规模项目密切相关。评估了收敛和发散的有效性。进行了探索性工厂分析以确定量表项目的因子结构,并使用提取因子的验证性工厂分析来评估模型拟合。
    结果:超过一半(60%)的抽样人群报告了至少一个ACE项目。所有四个PA项目均与融合结构显着相关(r=0.68,p<0.01)。在四个PA项目中,一个PA项目在收敛有效性方面显著优于其他三个项目,并用于创建新的ACE-PA量表项目(r=0.33,p<.01).通过新的PA项目加载确定了两个因素的解决方案,占方差的35%,当比较调整后的R2值(R2=0.35和R2=0.13)时,解释两个结果(R2=0.43和R2=0.16)比原始ACE量表更多的方差。局限性本研究使用参与者自我报告方法,使其具有回顾性偏见。
    结论:在人群中,新的PA项目与现有的ACE因素显著相关,暗示捕获额外的不良童年经历。
    BACKGROUND: Adver Childhood Experiences (ACEs) and Parental Alienation (PA)are forms of adverse events negatively affecting children globally. The current study was to identify a revised ACEs measure that includes a screening item for PA.
    METHODS: A total of 231 undergraduate students, ages 18 to 37, were surveyed for this analysis. A factor analyses was performed to identify what PA item, out of four, would correlate most strongly with existing ACEs scale items. Convergent and divergent validity was assessed. An exploratory factory analyses was conducted to identify factor structure of scale items and a confirmatory factory analysis of extracted factors was used to assess model fit.
    RESULTS: Over half (60 %) of the sampled population reported at least one ACEs item. All four PA items were significantly correlated with converging constructs (r = 0.68, p < .01). Out of four PA items, one PA item significantly outperformed the other three items in relation to convergent validity and was used to create a new ACEs-PA scale item (r = 0.33, p < .01). A two factor solution was identified with the new PA item loading, accounting for 35 % of the variance, explaining more variance in both outcomes (R2 = 0.43 and R2 = 0.16) than the original ACEs scale when comparing the adjusted R2 values (R2 = 0.35 and R2 = 0.13). Limitations This study used participant self-reporting methods subjecting it to retrospective bias.
    CONCLUSIONS: Within the population, the new PA item factored significantly with existing ACEs, suggesting the capture of an additional adverse childhood experience.
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  • 文章类型: Journal Article
    目的:评估联合生理-心理-社会评估问卷(UPPSAQ-70)在综合医院精神病门诊患者中的心理测量学特性。
    方法:共有2000名参与者回答了调查。因子分析用于检验量表的结构效度。通过UPPSAQ-70与使用中文版焦虑自评量表(SAS)测量的症状之间的相关性来评估收敛效度,抑郁自评量表(SDS),患者健康问卷-15(PHQ-15),躯体症状障碍-B标准量表(SSD-12)和匹兹堡睡眠质量指数(PSQI)。
    结果:支持九因素模型(χ2=8816.395,df=2309,χ2/df=3.818,RMSEA=0.053,CFI=0.929)。UPPSAQ-70与SAS显著相关(r=0.396,P<.001),SDS(r=0.451,P<.001),PHQ-15(r=0.381,P<.001),SSD-12(r=0.324,P<.001)和PSQI(r=0.220,P<.001)。UPPSAQ-70及其分量表显示出良好的内部一致性,Cronbach的α系数范围为0.79至0.96。
    结论:UPPSAQ-70是一个具有良好结构效度和信度的评定量表,可以测量生物的整体健康,心理,以及中国精神病门诊患者的社会领域,但其收敛效度仍需进一步实证研究。
    OBJECTIVE: To evaluate the psychometric properties of the Union Physio-Psycho-Social Assessment Questionnaire (UPPSAQ-70) among general hospital psychiatric outpatients.
    METHODS: A total of 2000 participants responded to the survey. Factor analyses were used to test the construct validity of the scale. Convergent validity was evaluated by the correlation between UPPSAQ-70 and symptoms measured using the Chinese versions of Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Patient Health Questionnaire-15 (PHQ-15), Somatic Symptom Disorder - B Criteria Scale (SSD-12) and Pittsburgh Sleep Quality Index (PSQI).
    RESULTS: The nine-factor model was supported (χ2 = 8816.395, df = 2309, χ2/df = 3.818, RMSEA = 0.053, CFI = 0.929). The UPPSAQ-70 showed significant correlation with the SAS (r = 0.396, P < .001), SDS (r = 0.451, P < .001), PHQ-15 (r = 0.381, P < .001), SSD-12 (r = 0.324, P < .001) and PSQI (r = 0.220, P < .001). UPPSAQ-70 and its subscales showed good internal consistency with Cronbach\'s alpha coefficients ranging from 0.79 to 0.96.
    CONCLUSIONS: The UPPSAQ-70 was a rating scale with good construct validity and reliability, which can measure overall health in the biological, psychological, and social domains for Chinese psychiatric outpatients, but its convergent validity still requires further empirical research.
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  • 文章类型: Journal Article
    许多护士加入这个行业是因为他们有利他的意图,但是一些护士在利他主义意图方面遇到障碍,这可能是工作不满或倦怠的根源。
    本研究的目的是评估结构效度,内部一致性,护理利他执行量表(NAES)的衔接信度,一种评估通过工作帮助他人的感知能力的新颖工具。
    NAES是根据文献综述研究利他行为作为护理工作的动机而开发的,与仪器改进的专家反馈。参与者完成了NAES,哥本哈根工作倦怠量表,和医务人员满意度调查。探索性因子分析检查了结构效度和因子载荷。验证性因子分析验证了因子结构的一致性。线性回归评估了具有倦怠和工作满意度的收敛可靠性。
    样本包括2023年1月至3月接受调查的843名急性护理医院护士。探索性因子分析揭示了一种双因素解决方案,名为利他参与工作和工作场所的利他主义障碍。保留了9个仪器项目,并显示出很强的内部一致性(Cronbach'salpha0.79)。NAES的两个因素与职业倦怠和工作满意度之间存在显着关系,证明更大的利他执行力与更低的倦怠和更高的工作满意度相关。
    初步发现支持使用NAES作为有效和可靠的量表。研究结果表明,利他主义意图与职业倦怠之间存在相关性。旨在增强利他主义执行力的干预措施可以减少护士的倦怠,从而提高保留率。
    UNASSIGNED: Many nurses join the profession because they have altruistic intentions, but some nurses experience barriers to acting on altruistic intentions which may be a source of job dissatisfaction or burnout.
    UNASSIGNED: The purpose of this study was to evaluate construct validity, internal consistency, and convergence reliability of the Nursing Altruistic Execution Scale (NAES), a novel instrument assessing the perceived ability to help others through work.
    UNASSIGNED: The NAES was developed based upon a literature review examining altruistic behavior as a motivator for nursing work, with expert feedback for instrument refinement. Participants completed the NAES, Copenhagen Burnout Inventory Work-Related Burnout Scale, and Satisfaction of Employees in Health Care Survey. Exploratory factor analysis examined construct validity and factor loadings. Confirmatory factor analysis verified consistency in factor structure. Linear regression assessed for convergence reliability with burnout and job satisfaction.
    UNASSIGNED: The sample included 843 acute care hospital nurses surveyed in January-March 2023. Exploratory factor analysis revealed a two-factor solution, named altruistic engagement with work and workplace barriers to altruism. Nine instrument items were retained and demonstrated strong internal consistency (Cronbach\'s alpha 0.79). There was a significant relationship between both factors of the NAES and both burnout and job satisfaction, demonstrating that greater altruistic execution is associated with lower burnout and greater job satisfaction.
    UNASSIGNED: Preliminary findings support the use of the NAES as a valid and reliable scale. Findings show there is correlation between altruistic intentions and burnout. Interventions aimed at enhancing altruistic execution may reduce nurse burnout and thereby improve retention.
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  • 文章类型: Journal Article
    建模的最新进展表明,绿叶蔬菜中的微生物失活遵循非线性模式,而不是简单的一级动力学。在这项研究中,我们评估了17个常用于描述微生物下降的失活模型,并建立了控制绿叶蔬菜微生物存活的条件。通过对65篇文章的系统回顾,我们提取了530个数据集来模拟产志贺毒素的大肠杆菌O157:H7在绿叶蔬菜上的命运。采用各种因素分析方法来评估所确定的条件对生存指标的影响。双参数模型(jm2)为大多数天然和抗菌诱导的持久性数据集提供了最佳拟合,而单参数指数模型提供了不到20%的数据集的最佳拟合。在拟合汇集的微生物存活数据方面,jm2模型(调整的R2=.89)也优于指数模型(调整的R2=.58)。在生存指标的背景下,对于>4个对数减少时间(LRT),模型平均方法比指数模型产生更高的值,这表明指数模型可能会在稍后的时间点过度预测失活。随机森林技术表明,温度和接种物大小是决定自然和抗微生物剂诱导死亡中失活的常见因素。.研究结果表明,在生产安全决策中,依赖1LRT的一阶生存度量和考虑非线性失活的局限性。
    Recent advancements in modeling suggest that microbial inactivation in leafy greens follows a nonlinear pattern, rather than the simple first-order kinetics. In this study, we evaluated 17 inactivation models commonly used to describe microbial decline and established the conditions that govern microbial survival on leafy greens. Through a systematic review of 65 articles, we extracted 530 datasets to model the fate of Shiga toxin-producing Escherichia coli O157:H7 on leafy greens. Various factor analysis methods were employed to evaluate the impact of identified conditions on survival metrics. A two-parameter model (jm2) provided the best fit to most of both natural and antimicrobial-induced persistence datasets, whereas the one-parameter exponential model provided the best fit to less than 20% of the datasets. The jm2 model (adjusted R2 = .89) also outperformed the exponential model (adjusted R2 = .58) in fitting the pooled microbial survival data. In the context of survival metrics, the model averaging approach generated higher values than the exponential model for >4 log reduction times (LRTs), suggesting that the exponential model may be overpredicting inactivation at later time points. The random forest technique revealed that temperature and inoculum size were common factors determining inactivation in both natural and antimicrobial-induced die-offs.. The findings show the limitations of relying on the first-order survival metric of 1 LRT and considering nonlinear inactivation in produce safety decision-making.
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  • 文章类型: Journal Article
    背景:社会关系的不同方面(例如,社交网络规模或孤独感)与痴呆症风险相关,虽然它们的重叠和潜在的潜在途径在很大程度上仍未被探索。因此,本研究旨在(1)通过因子分析区分社会关系的不同方面,(2)检查他们与痴呆风险的关联,(3)评估抑郁症状的调解。
    方法:将英国老龄化纵向研究(n=7536)的第2波(2004/2005)中有关社会关系的问卷中的36项用于探索性和验证性因素分析。然后将因素用作Cox比例风险模型中痴呆的预测因子,直到第9波为结果,调整人口统计学和心血管危险因素。结构方程模型通过效应分解检验了抑郁症状的中介作用。
    结果:因素分析确定了六个社会因素。平均随访时间为11.8年(IQR=5.9-13.9年),501人患上了痴呆症。与儿童接触的频率和质量因子得分较高(HR=0.88;p=0.021)和更频繁的社交活动参与(HR=0.84;p<0.001)与较低的痴呆风险相关。同样,较高的孤独感因子得分(HR=1.13;p=0.011)和负面的社会支持体验(HR=1.10;p=0.047)与较高的痴呆风险相关.中介分析显示,抑郁症状对所有四个因素均有显着的部分效果。其他分析几乎没有提供反向因果关系的证据。
    结论:社会交往的频率和质量,社交活动参与,孤独感与痴呆症风险相关,可能是痴呆症预防计划的合适目标,部分是通过降低抑郁症状。
    BACKGROUND: Different aspects of social relationships (e.g., social network size or loneliness) have been associated with dementia risk, while their overlap and potentially underlying pathways remain largely unexplored. This study therefore aimed to (1) discriminate between different facets of social relationships by means of factor analysis, (2) examine their associations with dementia risk, and (3) assess mediation by depressive symptoms.
    METHODS: Thirty-six items from questionnaires on social relationships administered in Wave 2 (2004/2005) of the English Longitudinal Study of Ageing (n = 7536) were used for exploratory and confirmatory factor analysis. Factors were then used as predictors in Cox proportional hazard models with dementia until Wave 9 as outcome, adjusted for demographics and cardiovascular risk factors. Structural equation modeling tested mediation by depressive symptoms through effect decomposition.
    RESULTS: Factor analyses identified six social factors. Across a median follow-up time of 11.8 years (IQR = 5.9-13.9 years), 501 people developed dementia. Higher factor scores for frequency and quality of contact with children (HR = 0.88; p = 0.021) and more frequent social activity engagement (HR = 0.84; p < 0.001) were associated with lower dementia risk. Likewise, higher factor scores for loneliness (HR = 1.13; p = 0.011) and negative experiences of social support (HR = 1.10; p = 0.047) were associated with higher dementia risk. Mediation analyses showed a significant partial effect mediation by depressive symptoms for all four factors. Additional analyses provided little evidence for reverse causation.
    CONCLUSIONS: Frequency and quality of social contacts, social activity engagement, and feelings of loneliness are associated with dementia risk and might be suitable targets for dementia prevention programs, partly by lowering depressive symptoms.
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  • 文章类型: Journal Article
    这项回顾性意向治疗研究旨在确定III期结核性脓胸患者从电视辅助胸腔镜手术(VATS)术中转换为开胸手术的相关危险因素。特别关注非多重耐药(MDR)/广泛耐药(XDR)病例。
    该研究纳入了122例非MDR/XDR结核性脓胸患者,他们最初计划进行VATS摘除。患者分为两组:胸腔镜组(n=64),成功接受了VATS摘除的人,和转换组(n=58),需要术中转换为开胸手术。复杂病例被排除在研究之外。分析只关注导致转化的因素,而不是整体治疗结果。
    两组患者术前常规糖皮质激素使用率存在显著差异,与胸腔镜检查组(75.0%)相比,转换组的百分比(46.5%)较低。此外,胸腔镜组显示手术前同侧肺异常的频率显著降低(37.5%),与转换组(65.5%)相反。多因素logistic回归分析显示,术前常规使用糖皮质激素(比值比(OR)=3.444,95%置信区间(CI):1.602~7.407)和既往存在肺部病变(OR=0.31,95CI:0.150~0.663)是潜在的影响因素。
    术前糖皮质激素给药不一致和同侧肺病变被确定为加重因素,导致术中肺组织挫伤或出血,从而导致VATS剥脱术的复杂性,因此阻碍了VATS摘除的成功完成,并需要转换为开胸手术。对这些因素的认识可以帮助外科医生对术前手术方法做出明智的决定。
    UNASSIGNED: This retrospective intention-to-treat study aims to identify risk factors associated with intraoperative conversion from Video-Assisted Thoracoscopic Surgery (VATS) Decortication to open thoracotomy in patients with Stage III Tuberculous Empyema, specifically focusing on non-Multi-Drug Resistant (MDR)/Extensively Drug-Resistant (XDR) cases.
    UNASSIGNED: The study included 122 patients with non-MDR/XDR tuberculous empyema who were initially scheduled for VATS decortication. Patients were divided into two groups: the Thoracoscopy group (n = 64), who successfully underwent VATS decortication, and the Conversion group (n = 58), who required intraoperative conversion to open thoracotomy. Complex cases were excluded from the study. The analysis focused solely on factors leading to conversion, rather than overall treatment outcomes.
    UNASSIGNED: A notable difference was observed in the rate of regular preoperative glucocorticoid utilization between the two cohorts, with the Conversion group exhibiting a lower percentage (46.5 %) in comparison to the Thoracoscopy group (75.0 %). Furthermore, the Thoracoscopy group displayed a significantly reduced frequency of ipsilateral lung abnormalities prior to the surgery (37.5 %), as opposed to that of the Conversion group (65.5 %). Multivariate logistic regression analysis revealed that the regular preoperative glucocorticoid use (odds ratio (OR) = 3.444, 95 % confidence interval (CI): 1.602-7.407) and pre-existing pulmonary lesions (OR = 0.31, 95%CI: 0.150-0.663) were potential influential factors.
    UNASSIGNED: Inconsistent preoperative glucocorticoid administration and ipsilateral lung lesions were identified as exacerbating factors leading to the complexity of VATS decortication by causing intraoperative pulmonary tissue contusion or hemorrhage, thus hindering the successful completion of VATS decortication and necessitating a conversion to thoracotomy. Awareness of these factors can aid surgeons in making well-informed decisions regarding the preoperative surgical approach.
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