PDF(Pubmed)
Abstract：
The present review aims to identify correlations between negative symptoms (NS) and deficits in neurocognition and social cognition in subjects with first-episode psychosis (FEP) and at-high-risk populations (HR). A systematic search of the literature published between 1 January 2005 and 31 December 2022 was conducted on PubMed, Scopus, and PsycInfo. Out of the 4599 records identified, a total of 32 studies met our inclusion/exclusion criteria. Data on a total of 3086 FEP and 1732 HR were collected. The available evidence shows that NS correlate with executive functioning and theory of mind deficits in FEP subjects, and with deficits in the processing speed, attention and vigilance, and working memory in HR subjects. Visual learning and memory do not correlate with NS in either FEP or HR subjects. More inconsistent findings were retrieved in relation to other cognitive domains in both samples. The available evidence is limited by sample and methodological heterogeneity across studies and was rated as poor or average quality for the majority of included studies in both FEP and CHR populations. Further research based on shared definitions of first-episode psychosis and at-risk states, as well as on more recent conceptualizations of negative symptoms and cognitive impairment, is highly needed.
摘要：
本综述旨在确定首发精神病（FEP）和高危人群（HR）的阴性症状（NS）与神经认知和社会认知缺陷之间的相关性。在PubMed上对2005年1月1日至2022年12月31日之间发表的文献进行了系统的搜索，Scopus,和PsycInfo。在确定的4599条记录中，共有32项研究符合我们的纳入/排除标准.收集总共3086FEP和1732HR的数据。现有证据表明，NS与FEP受试者的执行功能和心理缺陷理论相关，处理速度不足，注意和警惕，和HR科目中的工作记忆。在FEP或HR受试者中，视觉学习和记忆与NS无关。在两个样本中，与其他认知领域相关的发现更不一致。现有证据受研究样本和方法学异质性的限制，在FEP和CHR人群的大多数纳入研究中被评为质量差或平均。基于首发精神病和高危状态的共同定义的进一步研究，以及最近关于阴性症状和认知障碍的概念，是非常需要的。
